Genetic and Biochemical Characterization of VMB‐1, a Novel Metallo‐β‐Lactamase Encoded by a Conjugative, Broad‐Host Range IncC Plasmid from Vibrio spp
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Biosystems"
DOI: 10.1002/adbi.201900221
Abstract: The increasing incidence of phenotypic resistance to carbapenems in recent years is mainly attributed to acquisition of mobile carbapenemase‐encoding genetic elements by major bacterial pathogens. Here, a novel carbapenemase known as Vibrio metallo‐β‐lactamase 1 (VMB‐1),… read more here.
Keywords: vmb; vibrio; metallo; incc ... See more keywords
Mechanistic Investigations of Metallo‐β‐lactamase Inhibitors: Strong Zinc Binding Is Not Required for Potent Enzyme Inhibition**
Sign Up to like & getrecommendations! Published in 2021 at "Chemmedchem"
DOI: 10.1002/cmdc.202100042
Abstract: Metallo‐β‐lactamases (MBLs) are zinc‐dependent bacterial enzymes that inactivate essentially all classes of β‐lactam antibiotics including last‐resort carbapenems. At present there are no clinically approved MBL inhibitors, and in order to develop such agents it is… read more here.
Keywords: zinc; investigations metallo; mechanistic investigations; inhibition ... See more keywords
Rapid detection of the New Delhi metallo‐b‐lactamase 1 (NDM‐1) gene by loop‐mediated isothermal amplification (LAMP)
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.22323
Abstract: New Delhi Metallo‐b‐lactamase (NDM‐1) is an enzyme emerging around the world conferring resistance to a wide range of β‐lactams agents and whose early detection is extremely important. We proposed to standardize the detection of the… read more here.
Keywords: loop mediated; detection; new delhi; lactamase ndm ... See more keywords
Structural and biochemical analyses of the metallo-β-lactamase fold protein YhfI from Bacillus subtilis.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.08.106
Abstract: Metallo-β-lactamase (MBL) fold proteins play critical roles in diverse biological processes, such as DNA repair, RNA processing, detoxification, and metabolism. Although MBL fold proteins share a metal-bound αββα structure, they are highly heterogeneous in metal… read more here.
Keywords: yhfi; fold protein; metal; bacillus subtilis ... See more keywords
Synthesis and investigation of inhibitory activities of imidazole derivatives against the metallo-β-lactamase IMP-1.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103277
Abstract: Mutations in bacteria can result in antibiotic resistance due to the overuse or abuse of β-lactam antibiotics. One strategy which bacteria can become resistance toward antibiotics is secreting of metallo β-lactamase enzymes that can open… read more here.
Keywords: imp; investigation inhibitory; imidazole derivatives; synthesis investigation ... See more keywords
Bioisosteric investigation of ebselen: Synthesis and in vitro characterization of 1,2-benzisothiazol-3(2H)-one derivatives as potent New Delhi metallo-β-lactamase inhibitors.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.103873
Abstract: Carbapenem-resistant Enterobacteriaceae (CRE) producing New Delhi metallo-β-lactamase (NDM-1) cause untreatable bacterial infections, posing a significant threat to human health. In the present study, by employing the concept of bioisosteric replacement of the selenium moiety of… read more here.
Keywords: new delhi; benzisothiazol one; one derivatives; metallo lactamase ... See more keywords
H2dpa derivatives containing pentadentate ligands: An acyclic adjuvant potentiates meropenem activity in vitro and in vivo against metallo-β-lactamase-producing Enterobacterales.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113702
Abstract: The emergence and dissemination of metallo-β-lactamases (MBLs) producing Enterobacterales is a great concern for public health due to the limited therapeutic options. No MBL inhibitors are currently available in clinical practice. Herein, we synthesized a… read more here.
Keywords: containing pentadentate; derivatives containing; h2dpa derivatives; producing enterobacterales ... See more keywords
Molecular diversity of chromosomal metallo-β-lactamase genes in Elizabethkingia genus.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2020.105978
Abstract: Elizabethkingia genus is an opportunistic life-threatening pathogen with intrinsic multidrug-resistant phenotype. It is the only known microorganism with multi-chromosome-borne metallo-β-lactamase genes. To determine the diversity and distribution of MBLs BlaBlaB and BlaGOB in this genus,… read more here.
Keywords: blablab blagob; diversity; elizabethkingia genus; lactamase genes ... See more keywords
The N···H hydrogen bond strength in the transition state at the limiting step determines the reactivity of cephalosporins in the active site of L1 metallo-β-lactamase
Sign Up to like & getrecommendations! Published in 2019 at "Mendeleev Communications"
DOI: 10.1016/j.mencom.2019.09.004
Abstract: The combined quantum mechanics/molecular mechanics investigation followed by the detailed electron density analysis for 9 cephalosporin–L1 metallo-β-lactamase complexes revealed correlation between the N···H hydrogen bond strength in the transition state at the limiting step and… read more here.
Keywords: bond strength; state limiting; hydrogen bond; metallo lactamase ... See more keywords
Identification and control of two outbreaks of unrelated New Delhi metallo-β-lactamase-producing carbapenem-resistant Escherichia coli traced to the same endoscope defect.
Sign Up to like & getrecommendations! Published in 2023 at "Infection control and hospital epidemiology"
DOI: 10.1017/ice.2023.21
Abstract: We report 2 outbreaks of genetically unrelated carbapenem-resistant New Delhi metallo-β-lactamase-producing Escherichia coli caused by contaminated duodenoscopes. Using endoscopes with disposable end caps, adherence to the manufacturer's reprocessing instructions, routine audits, and manufacturer evaluation are… read more here.
Keywords: carbapenem resistant; escherichia coli; new delhi; metallo lactamase ... See more keywords
SAR Studies Leading to the Identification of a Novel Series of Metallo-β-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model
Sign Up to like & getrecommendations! Published in 2019 at "ACS Infectious Diseases"
DOI: 10.1021/acsinfecdis.8b00246
Abstract: The clinical effectiveness of carbapenem antibiotics such as meropenem is becoming increasingly compromised by the spread of both metallo-β-lactamase (MBL) and serine-β-lactamase (SBL) enzymes on mobile genetic elements, stimulating research to find new β-lactamase inhibitors… read more here.
Keywords: carbapenem; metallo lactamase; series metallo; lactamase inhibitors ... See more keywords