Metal‐Complexes Biomimetic of Metallo‐β‐Lactamases
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Inorganic Chemistry"
DOI: 10.1002/ejic.202500194
Abstract: Metallo‐β‐lactamases (MβLs) are bacterial Zn2+ dependent enzymes that catalyze the hydrolysis inactivating β‐lactam antibiotics. Understanding their mechanism is crucial for developing more potent antibiotics and for designing inhibitors of MβLs paving the way for more… read more here.
Keywords: metal complexes; complexes biomimetic; biomimetic metallo; metallo ... See more keywords
Direct Identification of IMP and VIM Metallo‐β‐Lactamases in Gram‐Negative Bacteria Using A‐MALDI
Sign Up to like & getrecommendations! Published in 2025 at "Rapid Communications in Mass Spectrometry"
DOI: 10.1002/rcm.10095
Abstract: Rapid and accurate identification of carbapenemase‐producing Enterobacteriaceae (CPE) is crucial for effective infection control and patient treatment. However, accurate identification of VIM and IMP metallo‐β‐lactamases remains still challenging using MALDI‐TOF MS. read more here.
Keywords: using maldi; vim; imp; identification ... See more keywords
Structure-based design of covalent inhibitors targeting metallo-β-lactamases.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112573
Abstract: The emergence and prevalence of metallo-β-lactamases (MβLs)-mediated bacterial resistance has seriously threatened the global health today. MβLs are deemed to be one of the most worrying bacterial resistance factors that hydrolyze nearly all β-lactam antibiotics.… read more here.
Keywords: covalent inhibitors; design covalent; covalent; metallo lactamases ... See more keywords
Stereochemically altered cephalosporins as potent inhibitors of New Delhi metallo-β-lactamases.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2022.114174
Abstract: Antibiotic resistance caused by β-lactamases, particularly metallo-β-lactamases, has been a major threat to public health globally. New Delhi metallo-β-lactamase-1 (NDM-1) represents one of the most important metallo-β-lactamases; the production of NDM-1 in bacterial pathogen significantly… read more here.
Keywords: new delhi; metallo lactamases; metallo; stereochemically altered ... See more keywords
N-Aryl Mercaptopropionamides as Broad-Spectrum Inhibitors of Metallo-β-Lactamases.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01755
Abstract: Drug-resistant pathogens pose a global challenge to public health as they cause diseases that are extremely difficult to cure. Metallo-β-lactamases (MBLs) are a diverse set of zinc-containing enzymes that catalyze the hydrolysis of β-lactam drugs,… read more here.
Keywords: aryl mercaptopropionamides; inhibitors metallo; spectrum inhibitors; mercaptopropionamides broad ... See more keywords
Computational and biological profile of boronic acids for the detection of bacterial serine- and metallo-β-lactamases
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-17399-7
Abstract: Abstractβ-Lactamases (BLs) able to hydrolyze β-lactam antibiotics and more importantly the last resort carbapenems, represent a major mechanism of resistance in Gram-negative bacteria showing multi-drug or extensively drug resistant phenotypes. The early detection of BLs… read more here.
Keywords: bls; detection; clinically relevant; metallo lactamases ... See more keywords
2-Mercaptomethyl-thiazolidines use conserved aromatic–S interactions to achieve broad-range inhibition of metallo-β-lactamases†
Sign Up to like & getrecommendations! Published in 2021 at "Chemical Science"
DOI: 10.1039/d0sc05172a
Abstract: Infections caused by multidrug resistant (MDR) bacteria are a major public health threat. Carbapenems are among the most potent antimicrobial agents that are commercially available to treat MDR bacteria. Bacterial production of carbapenem-hydrolysing metallo-β-lactamases (MBLs)… read more here.
Keywords: mercaptomethyl thiazolidines; thiazolidines use; use conserved; conserved aromatic ... See more keywords
The metallo-β-lactamases strike back: emergence of taniborbactam escape variants
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DOI: 10.1128/aac.01510-23
Abstract: ABSTRACT Metallo-β-lactamases (MBLs) have evolved relatively rapidly to become an international public health threat. There are no clinically available β-lactamase inhibitors with activity against MBLs. This may change with the introduction of cefepime-taniborbactam. Herein, we… read more here.
Keywords: 2024 https; agents chemother; https doi; metallo lactamases ... See more keywords
Active site loops of membrane-anchored metallo-β-lactamases from environmental bacteria determine cephalosporinase activity
Sign Up to like & getrecommendations! Published in 2025 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01918-24
Abstract: ABSTRACT Antimicrobial resistance is a significant global public health threat that limits treatment options for bacterial infections. This situation is aggravated by the environmental spread of β-lactamase genes. In particular, metallo-β-lactamases (MBLs) hydrolyze almost all… read more here.
Keywords: metallo lactamases; active site; membrane anchored; metallo ... See more keywords
Trade-Offs between Antibacterial Resistance and Fitness Cost in the Production of Metallo-β-Lactamases by Enteric Bacteria Manifest as Sporadic Emergence of Carbapenem Resistance in a Clinical Setting
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DOI: 10.1128/aac.02412-20
Abstract: Meropenem is a clinically important antibacterial reserved for treatment of multiresistant infections. In meropenem-resistant bacteria of the family Enterobacterales, New Delhi metallo-β-lactamase 1 (NDM-1) is considerably more common than IMP-1, despite both metallo-β-lactamases (MBLs) hydrolyzing… read more here.
Keywords: fitness; meropenem; metallo lactamases; resistance ... See more keywords
Drug development concerning metallo-β-lactamases in gram-negative bacteria
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.959107
Abstract: β-Lactams have been a clinical focus since their emergence and indeed act as a powerful tool to combat severe bacterial infections, but their effectiveness is threatened by drug resistance in bacteria, primarily by the production… read more here.
Keywords: concerning metallo; metallo; metallo lactamases; development concerning ... See more keywords