Metallodrug-Protein Interaction Probed by Synchrotron Terahertz and Neutron Scattering Spectroscopy.
Sign Up to like & getrecommendations! Published in 2021 at "Biophysical journal"
DOI: 10.1016/j.bpj.2021.06.012
Abstract: The present experimental work applied coherent synchrotron-radiation THz spectroscopy and inelastic neutron scattering to address two processes directly associated with the mode of action of metal-based anticancer agents, that can severely undermine chemotherapeutic treatment: drug… read more here.
Keywords: neutron scattering; metallodrug protein; drug; spectroscopy ... See more keywords
Versatile Tool for the Analysis of Metal-Protein Interactions Reveals the Promiscuity of Metallodrug-Protein Interactions.
Sign Up to like & getrecommendations! Published in 2017 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.7b02211
Abstract: Metallodrug-protein interactions contribute to their therapeutic effect (even when DNA is the dominant target), side-effects and are implicit in drug resistance. Here, we provide mass spectrometric-based evidence to show that metallodrug interactions with proteins are… read more here.
Keywords: protein; protein interactions; metallodrug protein; tool ... See more keywords