Ferriporphyrin-inspired MOFs as an artificial metalloenzyme for highly sensitive detection of H2O2 and glucose
Sign Up to like & getrecommendations! Published in 2020 at "Chinese Chemical Letters"
DOI: 10.1016/j.cclet.2020.03.052
Abstract: Abstract Metalloenzymes which employ metal species and organic ligands as central active sites play significant roles in various biological activities. Development of artificial metalloenzymes can help to understand the related physiological mechanism and promote the… read more here.
Keywords: h2o2 glucose; ferriporphyrin inspired; artificial metalloenzyme; highly sensitive ... See more keywords
An Artificial Metalloenzyme Based on a Copper Heteroscorpionate Enables sp3 C–H Functionalization via Intramolecular Carbene Insertion
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c03311
Abstract: The selective functionalization of sp3 C–H bonds is a versatile tool for the diversification of organic compounds. Combining attractive features of homogeneous and enzymatic catalysts, artificial metalloenzymes offer an ideal means to selectively modify these… read more here.
Keywords: functionalization; copper heteroscorpionate; artificial metalloenzyme; metalloenzyme ... See more keywords
Evolutionary Engineering of a Cp*Rh(III) Complex-Linked Artificial Metalloenzyme with a Chimeric β-Barrel Protein Scaffold
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.3c00581
Abstract: Evolutionary engineering of our previously reported Cp*Rh(III)-linked artificial metalloenzyme was performed based on a DNA recombination strategy to improve its catalytic activity toward C(sp2)–H bond functionalization. Improved scaffold design was achieved with α-helical cap domains… read more here.
Keywords: evolutionary engineering; artificial metalloenzyme; metalloenzyme; iii ... See more keywords
A metal ion regulated artificial metalloenzyme.
Sign Up to like & getrecommendations! Published in 2017 at "Dalton transactions"
DOI: 10.1039/c7dt00533d
Abstract: Regulation of enzyme activity is essential in living cells. The rapidly increasing number of designer enzymes with new-to-nature activities makes it necessary to develop novel strategies for controlling their catalytic activity. Here we present the… read more here.
Keywords: artificial metalloenzyme; metal ion; ion regulated; metalloenzyme ... See more keywords
Structure-Activity Relationships in Metal-Binding Pharmacophores for Influenza Endonuclease.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Medicinal Chemistry"
DOI: 10.2210/pdb6dzq/pdb
Abstract: Metalloenzymes represent an important target space for drug discovery. A limitation to the early development of metalloenzyme inhibitors has been the lack of established structure–activity relationships (SARs) for molecules that bind the metal ion cofactor(s)… read more here.
Keywords: activity relationships; metal binding; metal; structure activity ... See more keywords