Developing Metal-Binding Isosteres of 8-Hydroxyquinoline as Metalloenzyme Inhibitor Scaffolds.
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DOI: 10.1021/acs.inorgchem.2c00891
Abstract: The use of metal-binding pharmacophores (MBPs) in fragment-based drug discovery has proven effective for targeted metalloenzyme drug development. However, MBPs can still suffer from pharmacokinetic liabilities. Bioisostere replacement is an effective strategy utilized by medicinal… read more here.
Keywords: chemistry; metalloenzyme inhibitor; binding isosteres; drug ... See more keywords