Bacterial M10 metallopeptidase as a medicinal target - coordination chemistry of possible metal-based inhibition.
Sign Up to like & getrecommendations! Published in 2022 at "Dalton transactions"
DOI: 10.1039/d2dt02265f
Abstract: Streptococcus pneumoniae is the most frequent cause of fatal bacterial pneumonia infection worldwide. Due to the spreading of antibiotic-resistant pathogens, it is important to search for new therapeutic and prevention strategies against bacterial infections. It… read more here.
Keywords: inhibition; coordination; chemistry; metallopeptidase ... See more keywords
Structural insights into latency of the metallopeptidase ulilysin (lysargiNase) and its unexpected inhibition by a sulfonyl-fluoride inhibitor of serine peptidases.
Sign Up to like & getrecommendations! Published in 2023 at "Dalton transactions"
DOI: 10.1039/d3dt00458a
Abstract: Peptidases are regulated by latency and inhibitors, as well as compatibilization and cofactors. Ulilysin from Methanosarcina acetivorans, also called lysargiNase, is an archaeal metallopeptidase (MP) that is biosynthesized as a zymogen with a 60-residue N-terminal… read more here.
Keywords: lysarginase; metallopeptidase; inhibitor; sulfonyl fluoride ... See more keywords
Identification of the effects of acid-resistant Lactobacillus casei metallopeptidase gene under colon-specific promoter on the colorectal and breast cancer cell lines
Sign Up to like & getrecommendations! Published in 2021 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2021.53015.11950
Abstract: Objective(s): Anti-tumor effects of Lactobacilli as normal flora have been described. In a previous study, we identified a protein isolated from the bacterium Lactobacillus casei ATCC 39392 in acidic pH conditions named metallopeptidase. Therefore, we… read more here.
Keywords: metallopeptidase; cell lines; breast cancer; cancer cell ... See more keywords
Inactive metallopeptidase homologs: the secret lives of pseudopeptidases
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DOI: 10.3389/fmolb.2024.1436917
Abstract: Inactive enzyme homologs, or pseudoenzymes, are proteins, found within most enzyme families, that are incapable of performing catalysis. Rather than catalysis, they are involved in protein-protein interactions, sometimes regulating the activity of their active enzyme… read more here.
Keywords: homologs secret; lives pseudopeptidases; inactive metallopeptidase; metallopeptidase homologs ... See more keywords