Assessment of myocardial lipomatous metaplasia using an optimized out‐of‐phase cine steady‐state free‐precession sequence: Validation and clinical implementation
Sign Up to like & getrecommendations! Published in 2022 at "NMR in Biomedicine"
DOI: 10.1002/nbm.4777
Abstract: Myocardial lipomatous metaplasia, which can serve as substrate for ventricular arrhythmias, is usually composed of regions in which there is an admixture of fat and nonfat tissue. Although dedicated sequences for the detection of fat… read more here.
Keywords: myocardial lipomatous; ssfp; cine; metaplasia ... See more keywords
Deoxycholic acid-stimulated macrophage-derived exosomes promote intestinal metaplasia and suppress proliferation in human gastric epithelial cells.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173566
Abstract: The crosstalk between macrophages and gastric epithelial cells has emerged as a player in chronic inflammation during intestinal metaplasia. However, the role of bile acid on this modulation remains to be studied. We hypothesized that… read more here.
Keywords: gastric epithelial; intestinal metaplasia; epithelial cells; metaplasia ... See more keywords
Tristetraprolin prevents gastric metaplasia in mice by suppressing pathogenic inflammation.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and molecular gastroenterology and hepatology"
DOI: 10.1016/j.jcmgh.2021.07.015
Abstract: BACKGROUND & AIMS Aberrant immune activation is associated with numerous inflammatory and autoimmune diseases and contributes to cancer development and progression. Within the stomach, inflammation drives a well-established sequence from gastritis to metaplasia, eventually resulting… read more here.
Keywords: gastric inflammation; metaplasia; inflammation; ttp ... See more keywords
Opposing Wnt signals regulate cervical squamocolumnar homeostasis and emergence of metaplasia
Sign Up to like & getrecommendations! Published in 2021 at "Nature Cell Biology"
DOI: 10.1038/s41556-020-00619-0
Abstract: The transition zones of the squamous and columnar epithelia constitute hotspots for the emergence of cancer, often preceded by metaplasia, in which one epithelial type is replaced by another. It remains unclear how the epithelial… read more here.
Keywords: homeostasis; metaplasia; transition; opposing wnt ... See more keywords
Indoleamine 2,3-Dioxygenase 1, Increased in Human Gastric Pre-Neoplasia, Promotes Inflammation and Metaplasia in Mice and Is Associated With Type II Hypersensitivity/Autoimmunity.
Sign Up to like & getrecommendations! Published in 2018 at "Gastroenterology"
DOI: 10.1053/j.gastro.2017.09.002
Abstract: BACKGROUND & AIMS Chronic gastrointestinal inflammation increases the risk of cancer by mechanisms that are not well understood. Indoleamine-2,3-dioxygenase 1 (IDO1) is a heme-binding enzyme that regulates the immune response via catabolization and regulation of… read more here.
Keywords: metaplasia; control mice; inflammation; autoimmunity ... See more keywords
IL-33 triggers early eosinophil-dependent events leading to metaplasia in a chronic model of gastritis-prone mice.
Sign Up to like & getrecommendations! Published in 2020 at "Gastroenterology"
DOI: 10.1053/j.gastro.2020.09.040
Abstract: BACKGROUND & AIMS IL-33/IL-1F11 is an important mediator for the development of Th2-driven inflammatory disorders and has also been implicated in the pathogenesis of GI-related cancers, including gastric carcinoma. We therefore sought to mechanistically determine… read more here.
Keywords: eosinophil dependent; metaplasia; gastritis prone; leading metaplasia ... See more keywords
Glucocorticoids and androgens protect from gastric metaplasia by suppressing group 2 innate lymphoid cell activation.
Sign Up to like & getrecommendations! Published in 2021 at "Gastroenterology"
DOI: 10.1053/j.gastro.2021.04.075
Abstract: BACKGROUND AND AIMS The immune compartment is critical for maintaining tissue homeostasis. A weak immune response increases susceptibility to infection, but immune hyperactivation causes tissue damage, and chronic inflammation may lead to cancer development. In… read more here.
Keywords: gastric inflammation; metaplasia; glucocorticoids androgens; inflammation ... See more keywords
Single-cell transcriptomics reveals a conserved metaplasia program in pancreatic injury.
Sign Up to like & getrecommendations! Published in 2021 at "Gastroenterology"
DOI: 10.1053/j.gastro.2021.10.027
Abstract: BACKGROUND & AIMS Acinar to ductal metaplasia (ADM) occurs in the pancreas in response to tissue injury and is a potential precursor for adenocarcinoma. The goal of these studies was to define the populations arising… read more here.
Keywords: single cell; pancreatitis; metaplasia; program ... See more keywords
Apposition of fibroblasts with metaplastic gastric cells promotes dysplastic transition.
Sign Up to like & getrecommendations! Published in 2023 at "Gastroenterology"
DOI: 10.1053/j.gastro.2023.04.038
Abstract: BACKGROUND & AIMS Elements of field cancerization including atrophic gastritis, metaplasia and dysplasia promote gastric cancer development in association with chronic inflammation. However, it remains unclear how stroma changes during carcinogenesis and how the stroma… read more here.
Keywords: dysplastic transition; metaplasia cancer; apposition fibroblasts; metaplasia ... See more keywords
Adenocarcinoma of the cervical esophagus arising within a long segment of Barrett's metaplasia.
Sign Up to like & getrecommendations! Published in 2020 at "Endoscopy"
DOI: 10.1055/a-1207-0455
Abstract: A 53-year-old man was referred to the endoscopy unit for evaluation of noncardiac chest pain. He did not report dysphagia, gastroesophageal reflux disease symptoms, or weight loss. His medical record included hyperlipidemia and duodenal peptic… read more here.
Keywords: metaplasia; cervical esophagus; esophagus; barrett ... See more keywords
Endoscopic, histologic, and electron microscopic description of novel small vesicles with gastric heterotopia, intestinal metaplasia, and/or submucosal glands at the gastroesophageal junction.
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DOI: 10.1055/a-1792-2901
Abstract: The gastroesophageal junction (GEJ) is an ill-defined, physiologically and pathologically highly active transition zone connecting the esophagus to the stomach [1, 2]. Although several endoscopic and histologic aspects such as the Z-line, cardia, tongues, and/or… read more here.
Keywords: metaplasia; endoscopic histologic; yellow vesicles; gastroesophageal junction ... See more keywords