The genetic landscape of metaplastic breast cancers and uterine carcinosarcomas
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12813
Abstract: Metaplastic breast carcinoma (MBC) and uterine carcinosarcoma (UCS) are rare aggressive cancers, characterized by an admixture of adenocarcinoma and areas displaying mesenchymal/sarcomatoid differentiation. We sought to define whether MBCs and UCSs harbor similar patterns of… read more here.
Keywords: mbcs ucss; genetic alterations; metaplastic breast; alterations affecting ... See more keywords
The matricellular protein CCN6 differentially regulates mitochondrial metabolism in normal epithelium and in metaplastic breast carcinomas.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cell communication and signaling"
DOI: 10.1007/s12079-021-00657-9
Abstract: Metaplastic breast carcinoma (MBC) is an aggressive subtype of triple negative breast cancer with undefined precursors, limited response to chemotherapy, and frequent distant metastasis. Our laboratory has reported that CCN6/WISP3, a secreted protein that regulates… read more here.
Keywords: mmtv cre; breast; metaplastic breast; ccn6 ... See more keywords
In-depth characterization of a new patient-derived xenograft model for metaplastic breast carcinoma to identify viable biologic targets and patterns of matrix evolution within rare tumor types
Sign Up to like & getrecommendations! Published in 2021 at "Clinical and Translational Oncology"
DOI: 10.1007/s12094-021-02677-8
Abstract: Metaplastic breast carcinoma (MBC) is a rare breast cancer subtype with rapid growth, high rates of metastasis, recurrence and drug resistance, and diverse molecular and histological heterogeneity. Patient-derived xenografts (PDXs) provide a translational tool and… read more here.
Keywords: metaplastic breast; model; oncology; bcx 4ic ... See more keywords
IMP3 contributes to poor prognosis of patients with metaplastic breast carcinoma: A clinicopathological study.
Sign Up to like & getrecommendations! Published in 2017 at "Annals of diagnostic pathology"
DOI: 10.1016/j.anndiagpath.2017.05.015
Abstract: Metaplastic breast carcinoma (MBC) is a rare type of tumor with heterogenous histological patterns. We investigated the immunohistochemical expression of IMP3, an oncofetal protein, in 31 MBC patients in association with histological subtypes and clinical… read more here.
Keywords: imp3 low; carcinoma; breast carcinoma; metaplastic breast ... See more keywords
A genetic mutation panel for differentiating malignant phyllodes tumour from metaplastic breast carcinoma.
Sign Up to like & getrecommendations! Published in 2017 at "Pathology"
DOI: 10.1016/j.pathol.2017.07.011
Abstract: Phyllodes tumour (PT) is a biphasic breast neoplasm that is histologically composed of a proliferation of stromal and epithelial cells. PT is characterised by a prominent and exaggerated intracanalicular growth pattern with leaf-like stromal fronds… read more here.
Keywords: phyllodes tumour; breast; breast carcinoma; metaplastic breast ... See more keywords
Metaplastic breast carcinoma: a clinical-pathologic study of 97 cases with subset analysis of response to neoadjuvant chemotherapy
Sign Up to like & getrecommendations! Published in 2019 at "Modern Pathology"
DOI: 10.1038/s41379-019-0208-x
Abstract: Metaplastic breast carcinoma is a rare heterogeneous category of breast cancer, often associated with a poor prognosis. Clinical-pathologic studies with respect to varied morphologic subtypes are lacking. There is also a dearth of studies assessing… read more here.
Keywords: response; breast; breast carcinoma; metaplastic breast ... See more keywords
Genomic characterization and tumor evolution in paired samples of metaplastic breast carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Modern Pathology"
DOI: 10.1038/s41379-022-01017-7
Abstract: Metaplastic breast carcinomas are a rare and heterogeneous group of tumors (0.5–2%). They are mainly triple negative tumors but they present poorer chemotherapy responses and worse prognosis than other triple negative tumors. The aim of… read more here.
Keywords: tumor; tumor samples; relapse progression; metaplastic breast ... See more keywords
Dramatic response of metaplastic breast cancer to chemo-immunotherapy
Sign Up to like & getrecommendations! Published in 2017 at "NPJ Breast Cancer"
DOI: 10.1038/s41523-017-0011-0
Abstract: Frequent overexpression of programmed death-ligand 1 has recently been demonstrated in metaplastic breast cancer, which is a rare breast cancer subtype with limited treatment options. This report describes the clinical course of a patient with… read more here.
Keywords: response; breast; metaplastic breast; breast cancer ... See more keywords
Metaplastic breast cancer in a patient with neurofibromatosis type 1 and somatic loss of heterozygosity
Sign Up to like & getrecommendations! Published in 2018 at "Cold Spring Harbor Molecular Case Studies"
DOI: 10.1101/mcs.a002352
Abstract: Metaplastic breast carcinoma (MBC) is rare and has a poor prognosis. Here we describe genetic analysis of a 41-yr-old female patient with MBC and neurofibromatosis type I (NF1). She initially presented with pT3N1a, grade 3… read more here.
Keywords: breast; metaplastic breast; somatic loss; neurofibromatosis type ... See more keywords
TROP2, androgen receptor, and PD‐L1 status in histological subtypes of high‐grade metaplastic breast carcinomas
Sign Up to like & getrecommendations! Published in 2022 at "Histopathology"
DOI: 10.1111/his.14852
Abstract: High‐grade metaplastic breast carcinoma (HG‐MBC) is a rare subtype of invasive breast carcinoma, mostly triple‐negative. Metaplastic carcinomas are less responsive to neoadjuvant chemotherapy and are associated with a worse outcome than invasive carcinomas of no… read more here.
Keywords: carcinomas; high grade; breast; grade metaplastic ... See more keywords
Imaging characteristics of metaplastic breast cancer with osteoblastic differentiation
Sign Up to like & getrecommendations! Published in 2020 at "BMJ Case Reports"
DOI: 10.1136/bcr-2020-235050
Abstract: An 82-year-old female presented to her breast surgeon with a hard, painful mass in the left breast. Mammography demonstrated a new hyperdense mass with pleomorphic calcifications of trabeculated appearance. Ultrasound-guided biopsy demonstrated a hypoechoic mass… read more here.
Keywords: breast; osteoblastic differentiation; metaplastic breast; characteristics metaplastic ... See more keywords