Young-Onset Breast Cancer Outcomes by Time Since Recent Childbirth in Utah
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.36763
Abstract: Key Points Question Is a postpartum breast cancer diagnosis independently associated with risk for breast cancer metastasis or breast cancer–specific mortality? Findings In this cohort study including 2970 patients diagnosed with breast cancer at age… read more here.
Keywords: metastasis; biology; breast cancer; cancer diagnosis ... See more keywords
The endochondral bone protein CHM1 sustains an undifferentiated, invasive phenotype, promoting lung metastasis in Ewing sarcoma
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12057
Abstract: Ewing sarcomas (ES) are highly malignant, osteolytic bone or soft tissue tumors, which are characterized by EWS–ETS translocations and early metastasis to lung and bone. In this study, we investigated the role of the BRICHOS… read more here.
Keywords: bone protein; lung; metastasis; bone ... See more keywords
MTA1 drives malignant progression and bone metastasis in prostate cancer
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12360
Abstract: Prostate cancer often metastasizes to the bone, leading to morbidity and mortality. While metastasis‐associated protein 1 (MTA1) is highly overexpressed in metastatic tumors and bone metastatic lesions, its exact role in the development of metastasis… read more here.
Keywords: metastasis; bone; bone metastasis; prostate cancer ... See more keywords
Gene expression profiles of breast cancer metastasis according to organ site.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular oncology"
DOI: 10.1002/1878-0261.13021
Abstract: In advanced breast cancer, biomarker identification and patient selection using a metastatic tumor biopsy is becoming more necessary. However, the biology of metastasis according to the organ site is largely unknown. Here, we evaluated the… read more here.
Keywords: according organ; organ site; metastasis; expression ... See more keywords
Ryanodine receptor 2 promotes colorectal cancer metastasis by the ROS/BACH1 axis
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13350
Abstract: There is no targeted therapy for KRAS proto‐oncogene, GTPase (KRAS)‐mutant metastatic colorectal cancer (mCRC) because the underlying mechanism remains obscure. Based on bioinformatic analysis, this study aims to elucidate a potential gene target for which… read more here.
Keywords: metastasis; ryanodine receptor; expression; colorectal cancer ... See more keywords
Pancreatic cancer-derived small extracellular vesical ezrin activates fibroblasts to exacerbate cancer metastasis through STAT3 and YAP-1 signaling pathways.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular oncology"
DOI: 10.1002/1878-0261.13442
Abstract: Cancer-associated fibroblasts (CAFs), a major component of the tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC), play an important role in tumorigenesis, metastasis, and chemoresistance. Tumor-derived small extracellular vesicles (sEVs), which mediate cell-to-cell communication between… read more here.
Keywords: metastasis; pdac cell; pdac; cancer ... See more keywords
Histone demethylase KDM6B inhibits breast cancer metastasis by regulating Wnt/β‐catenin signaling
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13236
Abstract: Tumor metastasis remains a major challenge for patients with breast cancer. Aberrant epigenetic factor lysine‐specific demethylase 6B (KDM6B) has been associated with tumor progression. Here, we show that KDM6B is significantly down‐regulated in human breast… read more here.
Keywords: catenin; breast cancer; metastasis; cancer ... See more keywords
Metallodrugs: an approach against invasion and metastasis in cancer treatment
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13381
Abstract: Cancer is a heterogeneous and multifactorial disease that causes high mortality throughout the world; therefore, finding the most effective therapies is a major research challenge. Currently, most anticancer drugs present a limited number of well‐established… read more here.
Keywords: metastasis; metallodrugs approach; approach invasion; metastasis cancer ... See more keywords
Enhanced Prevention of Breast Tumor Metastasis by Nanoparticle-Delivered Vitamin E in Combination with Interferon-Gamma.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced healthcare materials"
DOI: 10.1002/adhm.201901706
Abstract: Preventing cancer metastasis is one of the remaining challenges in cancer therapy. As an efficient natural product, alpha-tocopheryl succinate (α-TOS), the most effective form of vitamin E, holds great anticancer potential. To improve its efficacy… read more here.
Keywords: combination; combination interferon; metastasis; interferon gamma ... See more keywords
Site‐Specific Polyplex on CCR7 Down‐Regulation and T Cell Elevation for Lymphatic Metastasis Blocking on Breast Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202201166
Abstract: Tumor metastasis contributes to high cancer mortality. Tumor cells in lymph nodes (LNs) are difficult to eliminate but underlie uncontrollable systemic metastasis. The CC chemokine receptor 7 (CCR7) is overexpressed in tumor cells and interacts… read more here.
Keywords: metastasis; ccr7; tumor cells; site specific ... See more keywords
Enhancing the Management of Metastatic Tumors by Robust Co-delivery of 5-fluorouracil/microRNA-10b inhibitor Using EGFR-targeted Nanovehicles.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202202989
Abstract: Invasion and metastasis of colorectal cancer (CRC) are the leading causes of death of patients with CRC. 5-fluorouracil (5-FU) has been widely used in clinic practice as the basic chemotherapy drug for CRC. However, it… read more here.
Keywords: metastasis; egfr targeted; 10b inhibitor; microrna 10b ... See more keywords