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   Articles with "metastasis" as a keyword



Young-Onset Breast Cancer Outcomes by Time Since Recent Childbirth in Utah

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recommendations! Published in 2022 at "JAMA Network Open"

DOI: 10.1001/jamanetworkopen.2022.36763

Abstract: Key Points Question Is a postpartum breast cancer diagnosis independently associated with risk for breast cancer metastasis or breast cancer–specific mortality? Findings In this cohort study including 2970 patients diagnosed with breast cancer at age… read more here.

Keywords: metastasis; biology; breast cancer; cancer diagnosis ... See more keywords

The endochondral bone protein CHM1 sustains an undifferentiated, invasive phenotype, promoting lung metastasis in Ewing sarcoma

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recommendations! Published in 2017 at "Molecular Oncology"

DOI: 10.1002/1878-0261.12057

Abstract: Ewing sarcomas (ES) are highly malignant, osteolytic bone or soft tissue tumors, which are characterized by EWS–ETS translocations and early metastasis to lung and bone. In this study, we investigated the role of the BRICHOS… read more here.

Keywords: bone protein; lung; metastasis; bone ... See more keywords

MTA1 drives malignant progression and bone metastasis in prostate cancer

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recommendations! Published in 2018 at "Molecular Oncology"

DOI: 10.1002/1878-0261.12360

Abstract: Prostate cancer often metastasizes to the bone, leading to morbidity and mortality. While metastasis‐associated protein 1 (MTA1) is highly overexpressed in metastatic tumors and bone metastatic lesions, its exact role in the development of metastasis… read more here.

Keywords: metastasis; bone; bone metastasis; prostate cancer ... See more keywords
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Gene expression profiles of breast cancer metastasis according to organ site.

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recommendations! Published in 2021 at "Molecular oncology"

DOI: 10.1002/1878-0261.13021

Abstract: In advanced breast cancer, biomarker identification and patient selection using a metastatic tumor biopsy is becoming more necessary. However, the biology of metastasis according to the organ site is largely unknown. Here, we evaluated the… read more here.

Keywords: according organ; organ site; metastasis; expression ... See more keywords

Ryanodine receptor 2 promotes colorectal cancer metastasis by the ROS/BACH1 axis

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recommendations! Published in 2022 at "Molecular Oncology"

DOI: 10.1002/1878-0261.13350

Abstract: There is no targeted therapy for KRAS proto‐oncogene, GTPase (KRAS)‐mutant metastatic colorectal cancer (mCRC) because the underlying mechanism remains obscure. Based on bioinformatic analysis, this study aims to elucidate a potential gene target for which… read more here.

Keywords: metastasis; ryanodine receptor; expression; colorectal cancer ... See more keywords

Pancreatic cancer-derived small extracellular vesical ezrin activates fibroblasts to exacerbate cancer metastasis through STAT3 and YAP-1 signaling pathways.

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recommendations! Published in 2023 at "Molecular oncology"

DOI: 10.1002/1878-0261.13442

Abstract: Cancer-associated fibroblasts (CAFs), a major component of the tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC), play an important role in tumorigenesis, metastasis, and chemoresistance. Tumor-derived small extracellular vesicles (sEVs), which mediate cell-to-cell communication between… read more here.

Keywords: metastasis; pdac cell; pdac; cancer ... See more keywords

E‐selectin affinity glycoproteomics reveals neuroendocrine proteins and the secretin receptor as a poor‐prognosis signature in colorectal cancer

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recommendations! Published in 2024 at "Molecular Oncology"

DOI: 10.1002/1878-0261.13733

Abstract: Colorectal cancer (CRC) cells express sialylated Lewis antigens (sLe), crucial for metastasis via E‐selectin binding. However, these glycoepitopes lack cancer specificity, and E‐selectin‐targeted glycoproteins remain largely unknown. Here, we established a framework for identifying metastasis‐linked… read more here.

Keywords: poor prognosis; colorectal cancer; cancer; selectin ... See more keywords
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Histone demethylase KDM6B inhibits breast cancer metastasis by regulating Wnt/β‐catenin signaling

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recommendations! Published in 2021 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.13236

Abstract: Tumor metastasis remains a major challenge for patients with breast cancer. Aberrant epigenetic factor lysine‐specific demethylase 6B (KDM6B) has been associated with tumor progression. Here, we show that KDM6B is significantly down‐regulated in human breast… read more here.

Keywords: catenin; breast cancer; metastasis; cancer ... See more keywords

Metallodrugs: an approach against invasion and metastasis in cancer treatment

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recommendations! Published in 2022 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.13381

Abstract: Cancer is a heterogeneous and multifactorial disease that causes high mortality throughout the world; therefore, finding the most effective therapies is a major research challenge. Currently, most anticancer drugs present a limited number of well‐established… read more here.

Keywords: metastasis; metallodrugs approach; approach invasion; metastasis cancer ... See more keywords

Self‐Delivered Transformable Nanosystem Capable of Enhancing Photodynamic Effectiveness and Multi‐Target Ameliorating Immunosuppression for Treatment of Breast Cancer and Lung Metastasis

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recommendations! Published in 2024 at "Advanced Functional Materials"

DOI: 10.1002/adfm.202405051

Abstract: Homogeneous distribution and adequate accumulation of photosensitizer in tumor are essential for effective photodynamic therapy (PDT). However, the intricate tumor microenvironment (TME) often poses great challenges to the deep penetration and retention of therapeutic agents… read more here.

Keywords: delivered transformable; tumor; immunosuppression; metastasis ... See more keywords
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Enhanced Prevention of Breast Tumor Metastasis by Nanoparticle-Delivered Vitamin E in Combination with Interferon-Gamma.

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recommendations! Published in 2020 at "Advanced healthcare materials"

DOI: 10.1002/adhm.201901706

Abstract: Preventing cancer metastasis is one of the remaining challenges in cancer therapy. As an efficient natural product, alpha-tocopheryl succinate (α-TOS), the most effective form of vitamin E, holds great anticancer potential. To improve its efficacy… read more here.

Keywords: combination; combination interferon; metastasis; interferon gamma ... See more keywords