KRAS promotes tumor metastasis and chemoresistance by repressing RKIP via the MAPK–ERK pathway in pancreatic cancer
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DOI: 10.1002/ijc.31248
Abstract: Oncogenic KRAS plays a crucial role in pancreatic ductal adenocarcinoma (PDAC) development and progression. However, the mechanism has not been clearly elucidated. RKIP is a tumor repressor, and loss of RKIP has been shown in… read more here.
Keywords: cancer; expression; metastasis chemoresistance; rkip ... See more keywords
Deubiquitinating enzyme USP9X regulates metastasis and chemoresistance in triple‐negative breast cancer by stabilizing Snail1
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30763
Abstract: Breast cancer is one of the most common malignancies in women worldwide. Triple‐negative breast cancer (TNBC) is a highly aggressive and metastatic subtype that has the characteristics of easy recurrence, poor prognosis as well as… read more here.
Keywords: breast cancer; triple negative; metastasis chemoresistance;
Abstract 3527: WNT5B drives osteosarcoma stemness, metastasis and chemoresistance
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DOI: 10.1158/1538-7445.am2023-3527
Abstract: Osteosarcoma is a pediatric bone cancer that has no targeted therapy and has had no treatment advances for the last three decades. Osteosarcoma frequently metastasizes to the lungs, reducing patient survival with metastatic disease to… read more here.
Keywords: metastasis chemoresistance; stem; wnt5b drives; wnt5b ... See more keywords
The Role and Therapeutic Perspectives of Sirtuin 3 in Cancer Metabolism Reprogramming, Metastasis, and Chemoresistance
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.910963
Abstract: Sirtuin 3 (SIRT3), the nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, acts as a metabolic modulator mainly located in mitochondria via regulating the process of the relevant biochemical processes by targeting crucial mediators. Recently, owing to its… read more here.
Keywords: reprogramming metastasis; metastasis chemoresistance; cancer; metabolism reprogramming ... See more keywords