Frequent loss of metastatic ability in subclones of Apc, Kras, Tgfbr2, and Trp53 mutant intestinal tumor organoids
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Science"
DOI: 10.1111/cas.15709
Abstract: Cancer evolution is explained by the accumulation of driver mutations and subsequent positive selection by acquired growth advantages, like Darwin's evolution theory. However, whether the negative selection of cells that have lost malignant properties contributes… read more here.
Keywords: ability; metastatic ability; tumor; loss metastatic ... See more keywords
BLIMP1 Induces Transient Metastatic Heterogeneity in Pancreatic Cancer.
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DOI: 10.1158/2159-8290.cd-17-0250
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is one of the most metastatic and deadly cancers. Despite the clinical significance of metastatic spread, our understanding of molecular mechanisms that drive PDAC metastatic ability remains limited. By generating a… read more here.
Keywords: induces transient; metastatic ability; blimp1; blimp1 induces ... See more keywords
An Ethanol Extract of Perilla frutescens Leaves Suppresses Adrenergic Agonist-Induced Metastatic Ability of Cancer Cells by Inhibiting Src-Mediated EMT
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28083414
Abstract: Previous studies have indicated that the adrenergic receptor signaling pathway plays a fundamental role in chronic stress-induced cancer metastasis. In this study, we investigated whether an ethanol extract of Perilla frutescens leaves (EPF) traditionally used… read more here.
Keywords: adrenergic agonist; ability cancer; cancer; metastatic ability ... See more keywords