Targeting mitochondrial metabolism for metastatic cancer therapy
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23436
Abstract: Primary tumors evolve metabolic mechanisms favoring glycolysis for adenosine triphosphate (ATP) generation and antioxidant defenses. In contrast, metastatic cells frequently depend on mitochondrial respiration and oxidative phosphorylation (OxPhos). This reliance of metastatic cells on OxPhos… read more here.
Keywords: mitochondrial metabolism; metastatic cancer; therapeutic agents; tumor ... See more keywords
Controlling metastatic cancer: the role of phytochemicals in cell signaling
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-019-02892-5
Abstract: PurposeCancer is a serious health issue and a leading cause of death worldwide. Most of the cancer patients (approximately 90%) do not die from the consequences of the primary tumor development, but due to a… read more here.
Keywords: role phytochemicals; controlling metastatic; cancer role; phytochemicals cell ... See more keywords
Clinical results after biliary drainage by endoscopic retrograde cholangiopancreatography for analysis of metastatic cancer survival and prognostic factors
Sign Up to like & getrecommendations! Published in 2020 at "Surgical Endoscopy"
DOI: 10.1007/s00464-020-08121-2
Abstract: Malignant biliary obstruction secondary to metastatic cancer is associated with poor prognosis. To the best of our knowledge, no previous study has investigated long-term survival and associated prognostic factors after biliary endoscopic retrograde cholangiopancreatography (ERCP)… read more here.
Keywords: analysis; treatment; drainage; metastatic cancer ... See more keywords
KISS1 in metastatic cancer research and treatment: potential and paradoxes
Sign Up to like & getrecommendations! Published in 2020 at "Cancer and Metastasis Reviews"
DOI: 10.1007/s10555-020-09868-9
Abstract: The significance of KISS1 goes beyond its original discovery as a metastasis suppressor. Its function as a neuropeptide involved in diverse physiologic processes is more well studied. Enthusiasm regarding KISS1 has cumulated in clinical trials… read more here.
Keywords: research; cancer research; kiss1 metastatic; research treatment ... See more keywords
Mechanobiology of Bone Metastatic Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Current Osteoporosis Reports"
DOI: 10.1007/s11914-021-00704-9
Abstract: In this review, we provide an overview of what is currently known about the impacts of mechanical stimuli on metastatic tumor-induced bone disease (TIBD). Further, we focus on the role of the osteocyte, the skeleton’s… read more here.
Keywords: mechanical stimuli; bone metastatic; mechanobiology bone; cancer ... See more keywords
Emerging roles for LPP in metastatic cancer progression
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cell Communication and Signaling"
DOI: 10.1007/s12079-017-0415-5
Abstract: LIM domain containing proteins are important regulators of diverse cellular processes, and play pivotal roles in regulating the actin cytoskeleton. Lipoma Preferred Partner (LPP) is a member of the zyxin family of LIM proteins that… read more here.
Keywords: lpp metastatic; emerging roles; cancer progression; metastatic cancer ... See more keywords
Impact of CT-based body composition parameters at baseline, their early changes and response in metastatic cancer patients treated with immune checkpoint inhibitors.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of radiology"
DOI: 10.1016/j.ejrad.2020.109340
Abstract: PURPOSE CT-based Body-composition (BC) parameters correlate with the patients' outcome in metastatic cancer patients treated with chemotherapies or targeted therapies. Our aim was to investigate similar associations regarding immune checkpoint inhibitor (CPI). METHODS Patients were… read more here.
Keywords: cancer patients; based body; body composition; composition parameters ... See more keywords
Psychometric Analysis of the Parenting Concerns Questionnaire in Women With Metastatic Cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of pain and symptom management"
DOI: 10.1016/j.jpainsymman.2017.09.021
Abstract: CONTEXT Parenting concerns are a major source of distress for patients with advanced cancer. However, validated tools to measure this construct in advanced cancer patients are lacking. OBJECTIVES The Parenting Concerns Questionnaire (PCQ) is the… read more here.
Keywords: pcq; analysis; concerns questionnaire; cancer ... See more keywords
Preferences for notification of imaging results in patients with metastatic cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Patient education and counseling"
DOI: 10.1016/j.pec.2019.08.032
Abstract: OBJECTIVE This study examines the preferences of patients with metastatic cancer regarding notification of imaging results, as well as distress surrounding the process. METHODS On imaging day, preferences for notification, expectations of results, health literacy,… read more here.
Keywords: imaging results; preferences notification; patients metastatic; notification ... See more keywords
A Contemporary Analysis of the 30-day Morbidity and Mortality Associated With Cytoreductive Nephrectomy.
Sign Up to like & getrecommendations! Published in 2020 at "Urology"
DOI: 10.1016/j.urology.2020.10.016
Abstract: OBJECTIVE To examine the rates of adverse surgical outcomes in patients undergoing cytoreductive nephrectomy (CN) compared to patients undergoing radical nephrectomy in the nonmetastatic setting using a large administrative database. METHODS Patients in the American… read more here.
Keywords: analysis; patients undergoing; mortality; cancer ... See more keywords
Cell-free DNA captures tumor heterogeneity and driver alterations in rapid autopsies with pre-treated metastatic cancer
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-23394-4
Abstract: In patients with metastatic cancer, spatial heterogeneity of somatic alterations may lead to incomplete assessment of a cancer’s mutational profile when analyzing a single tumor biopsy. In this study, we perform sequencing of cell-free DNA… read more here.
Keywords: free dna; driver alterations; cell free; cancer ... See more keywords