Cost-effectiveness Analysis of Genetic Testing and Tailored First-Line Therapy for Patients With Metastatic Gastrointestinal Stromal Tumors
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DOI: 10.1001/jamanetworkopen.2020.13565
Abstract: Key Points Question Is targeted gene testing cost-effective in patients with metastatic gastrointestinal stromal tumor? Findings This economic evaluation developed a Markov model to examine the cost-effectiveness of targeted gene testing with tailored imatinib dosing… read more here.
Keywords: metastatic gastrointestinal; patients metastatic; gastrointestinal stromal; testing tailored ... See more keywords
Clinical Importance of Clonal Hematopoiesis in Metastatic Gastrointestinal Tract Cancers
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DOI: 10.1001/jamanetworkopen.2022.54221
Abstract: Key Points Question To what extent is clonal hematopoiesis (CH) associated with treatment response and toxicity among patients with metastatic cancer who receive chemotherapy or immune checkpoint blockade? Findings In this cohort study of 633… read more here.
Keywords: metastatic gastrointestinal; hematopoiesis metastatic; importance clonal; clinical importance ... See more keywords
Prediction of morbidity following cytoreductive surgery for metastatic gastrointestinal stromal tumour in patients on tyrosine kinase inhibitor therapy
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DOI: 10.1002/bjs.10774
Abstract: Although cytoreductive surgery has been shown to be beneficial in carefully selected patients with metastatic gastrointestinal stromal tumours (GISTs) treated with tyrosine kinase inhibitors (TKIs), factors predictive of postoperative morbidity have not been investigated previously. read more here.
Keywords: surgery; metastatic gastrointestinal; gastrointestinal stromal; cytoreductive surgery ... See more keywords
Patient-derived organoids model treatment response of metastatic gastrointestinal cancers
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DOI: 10.1126/science.aao2774
Abstract: Cancer organoids to model therapy response Cancer organoids are miniature, three-dimensional cell culture models that can be made from primary patient tumors and studied in the laboratory. Vlachogiannis et al. asked whether such “tumor-in-a-dish” approaches… read more here.
Keywords: medicine; metastatic gastrointestinal; drug; organoids model ... See more keywords
Might Patients with Metastatic Gastrointestinal Stromal Tumors Benefit from Operative Management? A Population-Based Retrospective Study
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DOI: 10.1155/2022/9432410
Abstract: Background With respect to effect of surgery on the therapy of patients with metastatic gastrointestinal stromal tumors (mGISTs), still no consensus has been reached. This research designed to investigate the effect of surgical treatment on… read more here.
Keywords: stromal tumors; operative management; metastatic gastrointestinal; management ... See more keywords
Serial ctDNA Monitoring to Predict Response to Systemic Therapy in Metastatic Gastrointestinal Cancers
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DOI: 10.1158/1078-0432.ccr-19-3467
Abstract: Purpose: ctDNA offers a promising, noninvasive approach to monitor therapeutic efficacy in real-time. We explored whether the quantitative percent change in ctDNA early after therapy initiation can predict treatment response and progression-free survival (PFS) in… read more here.
Keywords: therapy; response; ctdna; tumor markers ... See more keywords
Locoregional Treatments for Metastatic Gastrointestinal Stromal Tumor in British Columbia: A Retrospective Cohort Study from January 2008 to December 2017
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DOI: 10.3390/cancers14061477
Abstract: Simple Summary It is not known if surgery, radiation treatment (RT) or other types of locolregional treatment (LRT) may be beneficial for patients with metastatic gastrointestinal stromal tumor (mGIST) in addition to systemic treatment. Our… read more here.
Keywords: stromal tumor; metastatic gastrointestinal; treatment; tumor ... See more keywords