Icaritin ameliorates extracellular microparticles‐induced inflammatory pre‐metastatic niche via modulating the cGAS‐STING signaling
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7433
Abstract: The concept of the inflammatory pre‐metastatic niche (PMN) provides a new and promising direction for the prevention and treatment of metastasis. The excessive activation of the GAS‐STING signaling leads to augmented metastasis by promoting the… read more here.
Keywords: pre metastatic; sting signaling; inflammatory pre; metastatic niche ... See more keywords
High throughput sequencing identifies breast cancer-secreted exosomal LncRNAs initiating pulmonary pre-metastatic niche formation.
Sign Up to like & getrecommendations! Published in 2019 at "Gene"
DOI: 10.1016/j.gene.2019.06.004
Abstract: OBJECTIVE Increasing evidence indicated that cancer-secreted exosomes played an important role in tumor metastasis. However, the function of exosomes in breast cancer pulmonary metastasis remains unknown. The aim of the study was to investigate the… read more here.
Keywords: pre metastatic; cancer secreted; niche formation; metastatic niche ... See more keywords
Liver Tropism in Cancer: The Hepatic Metastatic Niche.
Sign Up to like & getrecommendations! Published in 2019 at "Cold Spring Harbor perspectives in medicine"
DOI: 10.1101/cshperspect.a037259
Abstract: The liver is the largest organ in the human body and is prone for cancer metastasis. Although the metastatic pattern can differ depending on the cancer type, the liver is the organ to which cancer… read more here.
Keywords: metastatic niche; hepatic metastatic; liver tropism; cancer ... See more keywords
PO-305 Depletion of CPEB4 in the metastatic niche enhances metastatic growth
Sign Up to like & getrecommendations! Published in 2018 at "ESMO Open"
DOI: 10.1136/esmoopen-2018-eacr25.818
Abstract: Introduction Metastasis is the primary cause of death in cancer patients. The implantation and growth of metastatic cells in secondary organs is dependent on both cell-intrinsic factors and microenvironmental (‘host’) factors. Host cells are activated… read more here.
Keywords: cpeb4; cell; metastatic niche; growth ... See more keywords
Abstract 1230: The pre-metastatic niche establishment through the induction of the epithelial-to-mesenchymal transition by circulating exosomes in lymphangioleiomyomatosis (LAM): implication of the complement cascade
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1230
Abstract: Exosomes are a class of extra cellular vesicles (EVs), with a multi vesicular endosomal origin, that are released by all cell types, with sizes ranging from 30-150nm and a lipid bilayer membrane. They have been… read more here.
Keywords: lymphangioleiomyomatosis lam; derived exosomes; pre metastatic; niche establishment ... See more keywords
Abstract 3513: Developing a 3D biomimetic liver metastatic niche model for pancreatic cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3513
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is the 3rd leading cause of cancer death in the Unites States with a 5-year survival rate of only 11%. Early diagnosis is very difficult and thus 53% of patients are… read more here.
Keywords: liver metastatic; metastatic niche; cancer; model ... See more keywords
Abstract P6-01-18: Early detection of development of a pre-metastatic niche in lungs in response to primary breast tumor using Raman spectroscopy
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs16-p6-01-18
Abstract: Background: An alarmingly large proportion of cancer-related deaths result from metastatic cancers. Development of quick, reliable and non-invasive or minimally invasive approaches to objectively assess the secondary tissues (potentially in vivo) will be instrumental in… read more here.
Keywords: pre metastatic; metastatic niche; spectroscopy; cancer ... See more keywords
Pancreatic cancer-derived exosomes promote tumor metastasis and liver pre-metastatic niche formation
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.18831
Abstract: Exosomes play important roles in cell-cell communication, and are likely mediators of the metastatic cascade in cancer. This study examined the role of exosomes in pancreatic cancer cell adhesion, migration, and invasion. We isolated and… read more here.
Keywords: pre metastatic; metastatic niche; pancreatic cancer; metastasis ... See more keywords
MDSCs: Key Criminals of Tumor Pre-metastatic Niche Formation
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.00172
Abstract: The emergence of disseminated metastases remains the primary cause of mortality in cancer patients. Formation of the pre-metastatic niche (PMN), which precedes the establishment of tumor lesions, is critical for metastases. Bone marrow-derived myeloid cells… read more here.
Keywords: pre metastatic; metastatic niche; mdscs; formation ... See more keywords
Immune Modulation of Metastatic Niche Formation in the Bone
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.765994
Abstract: Bone metastasis is commonly seen in patients with breast cancer, prostate cancer and lung cancer. Tumor-intrinsic factors and the tumor microenvironment cooperate to affect the formation of bone metastatic niche. Within the bone microenvironment, immune… read more here.
Keywords: bone; metastatic niche; immune modulation; formation bone ... See more keywords
Liquid Biopsy in Pre-Metastatic Niche: From Molecular Mechanism to Clinical Application
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.958360
Abstract: Metastatic dissemination represents a hallmark of cancer that is responsible for the high mortality rate. Recently, emerging evidence demonstrates a time-series event—pre-metastatic niche (PMN) has a profound impact on cancer metastasis. Exosomes, cell-free DNA (cfDNA),… read more here.
Keywords: pre metastatic; metastatic niche; biopsy; liquid biopsy ... See more keywords