Tantalum–Zirconium Co‐Doped Metal–Organic Frameworks Sequentially Sensitize Radio–Radiodynamic–Immunotherapy for Metastatic Osteosarcoma
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DOI: 10.1002/advs.202206779
Abstract: Due to radiation resistance and the immunosuppressive microenvironment of metastatic osteosarcoma, novel radiosensitizers that can sensitize radiotherapy (RT) and antitumor immunity synchronously urgently needed. Here, the authors developed a nanoscale metal–organic framework (MOF, named TZM)… read more here.
Keywords: metastatic osteosarcoma; osteosarcoma; immunotherapy metastatic; metal organic ... See more keywords
Curcumin-encapsulated polymeric nanoparticles for metastatic osteosarcoma cells treatment
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DOI: 10.1007/s40843-017-9107-x
Abstract: Osteosarcoma is a high-class malignant bone cancer with a less than 20% five-year survival rate due to its early metastasis potential. There is an urgent need to develop a versatile and innoxious drug to treat… read more here.
Keywords: cur nps; metastatic osteosarcoma; treatment; curcumin encapsulated ... See more keywords
NGS-analysis to the rescue: dual checkpoint inhibition in metastatic osteosarcoma – a case report and review of the literature
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DOI: 10.1080/17843286.2019.1683129
Abstract: ABSTRACT Background: The prognosis and treatment of metastatic osteosarcoma have not changed in the last decades and the responses to chemotherapy in this setting are disappointing. In the past years, immunotherapy has found its place… read more here.
Keywords: literature; metastatic osteosarcoma; treatment; case ... See more keywords
Respiratory Failure in a Child With Pulmonary Metastatic Osteosarcoma and COVID-19.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Pediatric Hematology/Oncology"
DOI: 10.1097/mph.0000000000001897
Abstract: The novel coronavirus, SARS-CoV-2, causes much more severe disease in adults than in children. Although it is anticipated that immune compromised children and children with cancer may be at higher risk of developing severe or… read more here.
Keywords: metastatic osteosarcoma; child; pulmonary metastatic; disease ... See more keywords
Pathways of immune exclusion in metastatic osteosarcoma are associated with inferior patient outcomes
Sign Up to like & getrecommendations! Published in 2021 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2020-001772
Abstract: Background Current therapy for osteosarcoma pulmonary metastases (PMs) is ineffective. The mechanisms that prevent successful immunotherapy in osteosarcoma are incompletely understood. We investigated the tumor microenvironment of metastatic osteosarcoma with the goal of harnessing the… read more here.
Keywords: metastatic osteosarcoma; immune exclusion; osteosarcoma; patient outcomes ... See more keywords
Retrospective Analysis of Adoptive TIL Therapy plus Anti-PD1 Therapy in Patients with Chemotherapy-Resistant Metastatic Osteosarcoma
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DOI: 10.1155/2020/7890985
Abstract: Background The pathological subtype of osteosarcoma is one of the most common malignant bone tumors. Notably, chemotherapy-resistant metastatic osteosarcoma has been reported to cause significant mortality and shows poor prognosis with the currently available multidisciplinary… read more here.
Keywords: pd1 therapy; anti pd1; til; metastatic osteosarcoma ... See more keywords
Combination of gemcitabine and docetaxel: a regimen overestimated in refractory metastatic osteosarcoma?
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DOI: 10.1186/s12885-018-4872-x
Abstract: BackgroundThe combination of gemcitabine and docetaxel (GT) has been demonstrated to be effective against various types of solid tumors, including sarcoma. However, the regimen has not been confirmed in large, well-designed clinical trials in refractory… read more here.
Keywords: gemcitabine docetaxel; metastatic osteosarcoma; combination gemcitabine; refractory metastatic ... See more keywords
Metastatic osteosarcoma at diagnosis: Analysis of 92 cases from a single institution.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2021.39.15_suppl.e23506
Abstract: e23506 Background: Metastatic osteosarcoma (MOS) with synchronous metastases accounts for 20-25% of all new cases of osteosarcoma. Lungs are the most common site of metastases at presentation (80%) followed by Bone (10%). 5- years Overall… read more here.
Keywords: diagnosis; institution; metastatic osteosarcoma; site ... See more keywords
The expression of hydrogen sulfide-producing enzymes in primary and lung metastatic osteosarcoma.
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DOI: 10.14670/hh-18-438
Abstract: BACKGROUND Hydrogen sulfide (H₂S) is a novel gas transmitter signaling molecule. H₂S is synthesized by cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (MST). There have been no reports about the roles of these… read more here.
Keywords: osteosarcoma; primary osteosarcoma; expression; metastatic osteosarcoma ... See more keywords
The Combination of Anlotinib and Gemcitabine/Docetaxel in Patients with Metastatic Osteosarcoma Who Have Failed Standard Chemotherapy
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DOI: 10.2147/cmar.s378264
Abstract: Purpose The options for the second-line treatment of metastatic osteosarcoma are still limited. Anlotinib is a multi-kinase inhibitor which has shown promising efficacy and good tolerability in various cancer types. This retrospective study was conducted… read more here.
Keywords: gemcitabine docetaxel; combination; group; docetaxel patients ... See more keywords
Delivery of mGluR5 siRNAs by Iron Oxide Nanocages by Alternating Magnetic Fields for Blocking Proliferation of Metastatic Osteosarcoma Cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23147944
Abstract: Although osteosarcoma is the most common primary malignant bone tumor, chemotherapeutic drugs and treatment have failed to increase the five-year survival rate over the last three decades. We previously demonstrated that type 5 metabotropic glutamate… read more here.
Keywords: mglur5 sirnas; osteosarcoma cells; metastatic osteosarcoma; mglur5 ... See more keywords