Structure Reconstruction of LyP-1: Lc(LyP-1) Coupling by Amide Bond Inspires the Brain Metastatic Tumor Targeted Drug Delivery.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.7b00801
Abstract: The stability and binding affinity of targeting ligands are very important in active targeting drug delivery. Herein we used LyP-1 peptide as a model peptide to investigate chemical-biology-based strategies in the design of peptide ligands… read more here.
Keywords: lyp; drug delivery; metastatic tumor; brain metastatic ... See more keywords
miRNA-1246 in extracellular vesicles secreted from metastatic tumor induces drug resistance in tumor endothelial cells
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-92879-5
Abstract: Tumor endothelial cells (TECs) reportedly exhibit altered phenotypes. We have demonstrated that TECs acquire drug resistance with the upregulation of P-glycoprotein (P-gp, ABCB1), contrary to traditional assumptions. Furthermore, P-gp expression was higher in TECs of… read more here.
Keywords: drug resistance; metastatic tumor; highly metastatic; resistance ... See more keywords
Neutrophils Provide Lipids to Metastatic Tumor Cells, Fueling Growth.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2020-143
Abstract: Lung mesenchymal cells promoted neutrophil lipid storage; lipids were transferred to tumor cells. read more here.
Keywords: metastatic tumor; tumor cells; neutrophils provide; lipids metastatic ... See more keywords
Role of mTOR and VEGFR Inhibition in Prevention of Metastatic Tumor Growth in the Spine
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.00174
Abstract: Objective: Spinal metastatic disease remains a major problem of oncological diseases. Patients affected may suffer pain, spinal instability, and severe neurological deficits. Today, palliative surgery and radiotherapy are the mainstays of therapy. In contrast, preventive… read more here.
Keywords: inhibitor; treatment; metastatic tumor; group ... See more keywords
Clone Phylogenetics Reveals Metastatic Tumor Migrations, Maps, and Models
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14174326
Abstract: Simple Summary Metastasis is the spread of cancer cells across organs and is a major cause of cancer mortality. Analysis of tumor sequencing data provides a means toward the reconstruction of routes of metastatic cell… read more here.
Keywords: metastatic tumor; metastatic migration; analysis; migration histories ... See more keywords