Specific cannabinoids revive adaptive immunity by reversing immune evasion mechanisms in metastatic tumours
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.982082
Abstract: Emerging cancers are sculpted by neo-Darwinian selection for superior growth and survival but minimal immunogenicity; consequently, metastatic cancers often evolve common genetic and epigenetic signatures to elude immune surveillance. Immune subversion by metastatic tumours can… read more here.
Keywords: specific cannabinoids; revive adaptive; metastatic tumours; immunity reversing ... See more keywords
A novel cell-based screen identifies chemical entities that reverse the immune-escape phenotype of metastatic tumours
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1119607
Abstract: Genetic and epigenetic events have been implicated in the downregulation of the cellular antigen processing and presentation machinery (APM), which in turn, has been associated with cancer evasion of the immune system. When these essential… read more here.
Keywords: cell based; entities reverse; immune escape; metastatic tumours ... See more keywords