Evaluation of the modified immune prognostic index to prognosticate outcomes in metastatic uveal melanoma patients treated with immune checkpoint inhibitors
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Medicine"
DOI: 10.1002/cam4.3784
Abstract: Metastatic uveal melanoma (MUM) is associated with poor survival and inferior response to immune checkpoint inhibitor (ICI) therapy when compared with metastatic cutaneous melanoma. Currently, prognostic biomarkers are lacking to guide treatment decisions. read more here.
Keywords: uveal melanoma; immune checkpoint; evaluation modified; metastatic uveal ... See more keywords
Clinical determinants of long-term survival in metastatic uveal melanoma
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DOI: 10.1007/s00262-021-03090-4
Abstract: This study aimed to identify prognostic factors in patients with metastatic uveal melanoma (UM) that were associated with long-term survival in a real-world setting. A total of 94 patients with metastatic UM were included from… read more here.
Keywords: term; response; long term; metastatic uveal ... See more keywords
Inflammatory cell infiltrates in advanced metastatic uveal melanoma.
Sign Up to like & getrecommendations! Published in 2017 at "Human pathology"
DOI: 10.1016/j.humpath.2017.06.005
Abstract: Current treatments for metastatic uveal melanoma (mUM) are limited and rarely prolong patient survival. Immunotherapy trials for mUM are few and to date have demonstrated only marginal success. High densities of tumor-associated macrophages (TAMs) and… read more here.
Keywords: within mum; cd68 cd163; density; uveal melanoma ... See more keywords
Palliative endoscopic treatment of metastatic uveal melanoma to the upper and lower urinary tract.
Sign Up to like & getrecommendations! Published in 2020 at "Urology"
DOI: 10.1016/j.urology.2020.04.075
Abstract: We report a rare case of uveal melanoma demonstrating simultaneous metastatic foci to the upper and lower urinary tract. A 60-year-old female with metastatic uveal melanoma was referred for incidental right hydronephrosis. Diagnostic cystoscopy and… read more here.
Keywords: melanoma; urinary tract; upper lower; uveal melanoma ... See more keywords
Molecular profiling of driver events in metastatic uveal melanoma
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DOI: 10.1038/s41467-020-15606-0
Abstract: Metastatic uveal melanoma is less well understood than its primary counterpart, has a distinct biology compared to skin melanoma, and lacks effective treatments. Here we genomically profile metastatic tumors and infiltrating lymphocytes. BAP1 alterations are… read more here.
Keywords: melanoma; molecular profiling; uveal melanoma; metastatic uveal ... See more keywords
Identification of novel chemotherapeutic strategies for metastatic uveal melanoma
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DOI: 10.1038/srep44564
Abstract: Melanoma of the uveal tract accounts for approximately 5% of all melanomas and represents the most common primary intraocular malignancy. Despite improvements in diagnosis and more effective local therapies for primary cancer, the rate of… read more here.
Keywords: chemotherapeutic strategies; uveal melanoma; identification novel; metastatic uveal ... See more keywords
Metastatic uveal melanoma managed with best supportive care
Sign Up to like & getrecommendations! Published in 2020 at "Acta Oncologica"
DOI: 10.1080/0284186x.2020.1817978
Abstract: As long as 25 years after treatment of primary uveal melanoma (UM), metastases are the leading cause of death and, eventually, over 50% of patients die of metastatic disease [1,2]. The liver is the... read more here.
Keywords: uveal melanoma; melanoma managed; metastatic uveal; melanoma ... See more keywords
Tebentafusp in advanced uveal melanoma: proof of principle for the efficacy of T-cell receptor therapeutics and bispecifics in solid tumors
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Biological Therapy"
DOI: 10.1080/14712598.2022.2031970
Abstract: ABSTRACT Introduction Tebentafusp is a novel bispecific immune mobilizing T cell receptor (TCR)-based agent developed for the treatment of metastatic uveal melanoma, a highly fatal disease with no currently approved treatment options. Recent evidence suggests… read more here.
Keywords: melanoma; uveal melanoma; metastatic uveal; efficacy ... See more keywords
Tebentafusp for the treatment of HLA-A*02:01–positive adult patients with unresectable or metastatic uveal melanoma
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DOI: 10.1080/14737140.2022.2124971
Abstract: ABSTRACT Introduction Metastatic uveal melanoma is associated with poor prognosis and few treatment options. Tebentafusp recently became the first FDA-approved agent for metastatic uveal melanoma. Areas covered In this review, we describe the mechanism of… read more here.
Keywords: hla; uveal melanoma; metastatic uveal; treatment ... See more keywords
Nivolumab plus ipilimumab in metastatic uveal melanoma: a real-life, retrospective cohort of 47 patients
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DOI: 10.1080/2162402x.2022.2116845
Abstract: ABSTRACT Although combined PD-1/CTLA-4 inhibition showed limited efficacy in single-arm, phase II trials in metastatic uveal melanoma (mUM), such combination appears frequently used in mUM patients. We here report our experience with nivolumab/ipilimumab in mUM.… read more here.
Keywords: metastatic uveal; combination; retrospective cohort; nivolumab ipilimumab ... See more keywords
Overall survival after treatment for metastatic uveal melanoma: a systematic review and meta-analysis
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DOI: 10.1097/cmr.0000000000000575
Abstract: Supplemental Digital Content is available in the text. read more here.
Keywords: uveal melanoma; metastatic uveal; treatment metastatic; melanoma ... See more keywords