Involvement of mTOR, JNK and PI3K in the negative effect of ethanol and metformin on the human first‐trimester extravillous trophoblast HTR‐8/SVneo cell line
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DOI: 10.1016/j.ejphar.2018.05.038
Abstract: Abstract Our aim was to investigate the effect of two xenobiotics to which pregnant woman may be exposed, the drug of abuse ethanol (EtOH) (and its metabolite acetaldehyde (ACA)) and the therapeutic agent metformin (METF),… read more here.
Keywords: metf; jnk pi3k; htr svneo; mtor jnk ... See more keywords
Metformin Counteracts HCC Progression and Metastasis Enhancing KLF6/p21 Expression and Downregulating the IGF Axis
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DOI: 10.1155/2019/7570146
Abstract: Background and Aims Hepatocellular carcinoma (HCC) is the common tumor of the liver. Unfortunately, most HCC seem to be resistant to conventional chemotherapy and radiotherapy. The poor efficacy of antitumor agents is also due, at… read more here.
Keywords: metf; igf axis; hcc; klf6 p21 ... See more keywords