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   Articles with "metformin" as a keyword



Association of Metformin Use With Risk of Lactic Acidosis Across the Range of Kidney Function: A Community-Based Cohort Study

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recommendations! Published in 2018 at "JAMA Internal Medicine"

DOI: 10.1001/jamainternmed.2018.0292

Abstract: Importance Approximately 1 million patients in the United States with type 2 diabetes mellitus and mild-to-moderate kidney disease do not receive guideline-directed therapy with metformin. This may reflect uncertainty regarding the risk of acidosis in… read more here.

Keywords: acidosis; use; egfr min; metformin ... See more keywords

Association of Metformin With the Development of Age-Related Macular Degeneration.

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recommendations! Published in 2022 at "JAMA ophthalmology"

DOI: 10.1001/jamaophthalmol.2022.5567

Abstract: Importance Age-related macular degeneration (AMD) is a leading cause of blindness with no treatment available for early stages. Retrospective studies have shown an association between metformin and reduced risk of AMD. Objective To investigate the… read more here.

Keywords: arm; age related; association metformin; age ... See more keywords

Metformin Impairs Breast Cancer Growth through the Inhibition of PRMT6.

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recommendations! Published in 2025 at "Advanced science"

DOI: 10.1002/advs.202508525

Abstract: Metformin is the world's widely prescribed oral medication for the treatment of type 2 diabetes mellitus, which is also shown to repress tumorigenesis without a complete understanding of its therapeutic targets. Here, it is shown… read more here.

Keywords: prmt6; breast cancer; cancer growth; metformin ... See more keywords
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The effects of high-fat diet and metformin on urinary metabolites in diabetes and pre-diabetes rat models.

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recommendations! Published in 2020 at "Biotechnology and applied biochemistry"

DOI: 10.1002/bab.2021

Abstract: High-fat diet (HFD) interferes with the dietary plan of patients with type 2 diabetes mellitus (T2DM). However, many diabetes patients consume food with higher fat content for a better taste bud experience. In this study,… read more here.

Keywords: fat diet; pre diabetes; hfd; diabetes pre ... See more keywords

Breast cancer risk for women with diabetes and the impact of metformin: A meta-analysis.

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recommendations! Published in 2022 at "Cancer medicine"

DOI: 10.1002/cam4.5545

Abstract: BACKGROUND Diabetes mellitus has been associated with increased breast cancer (BC) risk; however, the magnitude of this effect is uncertain. This study focused on BC risk for women with type 2 diabetes mellitus (T2DM). METHODS… read more here.

Keywords: meta; breast cancer; risk; metformin ... See more keywords

Investigating the effects of Ceylon cinnamon water extract on HepG2 cells for Type 2 diabetes therapy

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recommendations! Published in 2023 at "Cell Biochemistry and Function"

DOI: 10.1002/cbf.3778

Abstract: Cinnamon and its extracts have been used as herbal remedies for many ailments, including for reducing insulin resistance and diabetes complications. Type 2 diabetes mellitus (T2DM) is a rapidly growing health concern around the world.… read more here.

Keywords: cwe metformin; expression; gene expression; metformin ... See more keywords
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Metformin attenuates lipopolysaccharide‐induced epithelial cell senescence by activating autophagy

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recommendations! Published in 2020 at "Cell Biology International"

DOI: 10.1002/cbin.11536

Abstract: Acute lung injury (ALI) is a life‐threatening medical condition with higher mortality and morbidity in elderly patients. Recently, metformin, a drug commonly used to lower blood glucose in type 2 diabetes patients, has been shown… read more here.

Keywords: epithelial cell; cell senescence; atg5; senescence ... See more keywords

A Drug‐Drug Interaction Study to Evaluate the Impact of Rimegepant on OCT2‐ and MATE1‐Mediated Transport of Metformin in Healthy Participants

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recommendations! Published in 2024 at "Clinical Pharmacology in Drug Development"

DOI: 10.1002/cpdd.1352

Abstract: Rimegepant is a calcitonin gene‐related peptide receptor antagonist approved for migraine treatment. This phase 1, open‐label, single‐center, fixed‐sequence study evaluated the effect of rimegepant on the pharmacokinetics (PK) of metformin. Twenty‐eight healthy participants received metformin… read more here.

Keywords: healthy participants; daily days; study; drug ... See more keywords

No Effect of Plazomicin on the Pharmacokinetics of Metformin in Healthy Subjects

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recommendations! Published in 2019 at "Clinical Pharmacology in Drug Development"

DOI: 10.1002/cpdd.648

Abstract: Plazomicin is an aminoglycoside that was engineered to overcome aminoglycoside‐modifying enzymes, which are the most common aminoglycoside resistance mechanism in Enterobacteriaceae. Because plazomicin is predominantly eliminated via renal pathways, an in vitro study was conducted… read more here.

Keywords: plasma concentration; metformin; time; healthy subjects ... See more keywords
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Comparison of the Pharmacokinetics of a Fixed‐Dose Combination of Rosuvastatin/Metformin Sustained‐Release (10/1000 mg) and Separate Tablets in Healthy Male Subjects

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recommendations! Published in 2020 at "Clinical Pharmacology in Drug Development"

DOI: 10.1002/cpdd.841

Abstract: Fixed‐dose combination (FDC) drugs with various dose combinations for the treatment of type 2 diabetes mellitus and dyslipidemia are currently in demand. We compared the pharmacokinetic (PK) profiles of the rosuvastatin/metformin sustained‐release (10/1000 mg) FDC… read more here.

Keywords: rosuvastatin metformin; metformin; sustained release; metformin sustained ... See more keywords

Variants in Pharmacokinetic Transporters and Glycemic Response to Metformin: A Metgen Meta‐Analysis

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recommendations! Published in 2017 at "Clinical Pharmacology and Therapeutics"

DOI: 10.1002/cpt.567

Abstract: Therapeutic response to metformin, a first‐line drug for type 2 diabetes (T2D), is highly variable, in part likely due to genetic factors. To date, metformin pharmacogenetic studies have mainly focused on the impact of variants… read more here.

Keywords: response metformin; response; analysis; metformin ... See more keywords