Association of Metformin Use With Risk of Lactic Acidosis Across the Range of Kidney Function: A Community-Based Cohort Study
Sign Up to like & getrecommendations! Published in 2018 at "JAMA Internal Medicine"
DOI: 10.1001/jamainternmed.2018.0292
Abstract: Importance Approximately 1 million patients in the United States with type 2 diabetes mellitus and mild-to-moderate kidney disease do not receive guideline-directed therapy with metformin. This may reflect uncertainty regarding the risk of acidosis in… read more here.
Keywords: acidosis; use; egfr min; metformin ... See more keywords
Association of Metformin With the Development of Age-Related Macular Degeneration.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA ophthalmology"
DOI: 10.1001/jamaophthalmol.2022.5567
Abstract: Importance Age-related macular degeneration (AMD) is a leading cause of blindness with no treatment available for early stages. Retrospective studies have shown an association between metformin and reduced risk of AMD. Objective To investigate the… read more here.
Keywords: arm; age related; association metformin; age ... See more keywords
The effects of high-fat diet and metformin on urinary metabolites in diabetes and pre-diabetes rat models.
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology and applied biochemistry"
DOI: 10.1002/bab.2021
Abstract: High-fat diet (HFD) interferes with the dietary plan of patients with type 2 diabetes mellitus (T2DM). However, many diabetes patients consume food with higher fat content for a better taste bud experience. In this study,… read more here.
Keywords: fat diet; pre diabetes; hfd; diabetes pre ... See more keywords
Breast cancer risk for women with diabetes and the impact of metformin: A meta-analysis.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer medicine"
DOI: 10.1002/cam4.5545
Abstract: BACKGROUND Diabetes mellitus has been associated with increased breast cancer (BC) risk; however, the magnitude of this effect is uncertain. This study focused on BC risk for women with type 2 diabetes mellitus (T2DM). METHODS… read more here.
Keywords: meta; breast cancer; risk; metformin ... See more keywords
Investigating the effects of Ceylon cinnamon water extract on HepG2 cells for Type 2 diabetes therapy
Sign Up to like & getrecommendations! Published in 2023 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3778
Abstract: Cinnamon and its extracts have been used as herbal remedies for many ailments, including for reducing insulin resistance and diabetes complications. Type 2 diabetes mellitus (T2DM) is a rapidly growing health concern around the world.… read more here.
Keywords: cwe metformin; expression; gene expression; metformin ... See more keywords
Metformin attenuates lipopolysaccharide‐induced epithelial cell senescence by activating autophagy
Sign Up to like & getrecommendations! Published in 2020 at "Cell Biology International"
DOI: 10.1002/cbin.11536
Abstract: Acute lung injury (ALI) is a life‐threatening medical condition with higher mortality and morbidity in elderly patients. Recently, metformin, a drug commonly used to lower blood glucose in type 2 diabetes patients, has been shown… read more here.
Keywords: epithelial cell; cell senescence; atg5; senescence ... See more keywords
No Effect of Plazomicin on the Pharmacokinetics of Metformin in Healthy Subjects
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DOI: 10.1002/cpdd.648
Abstract: Plazomicin is an aminoglycoside that was engineered to overcome aminoglycoside‐modifying enzymes, which are the most common aminoglycoside resistance mechanism in Enterobacteriaceae. Because plazomicin is predominantly eliminated via renal pathways, an in vitro study was conducted… read more here.
Keywords: plasma concentration; metformin; time; healthy subjects ... See more keywords
Comparison of the Pharmacokinetics of a Fixed‐Dose Combination of Rosuvastatin/Metformin Sustained‐Release (10/1000 mg) and Separate Tablets in Healthy Male Subjects
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.841
Abstract: Fixed‐dose combination (FDC) drugs with various dose combinations for the treatment of type 2 diabetes mellitus and dyslipidemia are currently in demand. We compared the pharmacokinetic (PK) profiles of the rosuvastatin/metformin sustained‐release (10/1000 mg) FDC… read more here.
Keywords: rosuvastatin metformin; metformin; sustained release; metformin sustained ... See more keywords
Variants in Pharmacokinetic Transporters and Glycemic Response to Metformin: A Metgen Meta‐Analysis
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DOI: 10.1002/cpt.567
Abstract: Therapeutic response to metformin, a first‐line drug for type 2 diabetes (T2D), is highly variable, in part likely due to genetic factors. To date, metformin pharmacogenetic studies have mainly focused on the impact of variants… read more here.
Keywords: response metformin; response; analysis; metformin ... See more keywords
Direct injection analysis of oxypurinol and metformin in wastewater by hydrophilic interaction liquid chromatography coupled to tandem mass spectrometry.
Sign Up to like & getrecommendations! Published in 2022 at "Drug testing and analysis"
DOI: 10.1002/dta.3266
Abstract: The increasing global prevalence of gout and diabetes has led to a rise in the use of their respective medications, allopurinol and metformin. These are excreted via urine as oxypurinol and metformin, and are discharged… read more here.
Keywords: wastewater; direct injection; metformin wastewater; oxypurinol metformin ... See more keywords
Connecting the dots between metformin and high‐grade glioma
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DOI: 10.1002/ijc.31987
Abstract: Dear Editor, It was with great interest I read the recently published study by Seliger et al. evaluating the prognostic effect of diabetic metformin in high-grade glioma (HGG) patients. The authors should be commended on… read more here.
Keywords: glioma; grade glioma; grade; metformin ... See more keywords