Combined metformin-associated lactic acidosis and euglycemic ketoacidosis
Sign Up to like & getrecommendations! Published in 2017 at "Wiener Klinische Wochenschrift"
DOI: 10.1007/s00508-017-1251-6
Abstract: SummaryBackgroundIn renal failure metformin can lead to lactic acidosis. Additional inhibition of hepatic gluconeogenesis by accumulation of the drug may aggravate fasting-induced ketoacidosis. We report the occurrence of metformin-associated lactic acidosis (MALA) with concurrent euglycemic… read more here.
Keywords: metformin associated; lactic acidosis; ketoacidosis; associated lactic ... See more keywords
The Association between Metformin Therapy and Lactic Acidosis
Sign Up to like & getrecommendations! Published in 2019 at "Drug Safety"
DOI: 10.1007/s40264-019-00854-x
Abstract: There is increasing evidence to suggest that therapeutic doses of metformin are unlikely to cause lactic acidosis. The aims of this research were (1) to formally evaluate the association between metformin therapy and lactic acidosis… read more here.
Keywords: acidosis; metformin associated; lactic acidosis; association ... See more keywords
Expanding the evidence for managing metformin poisoning to support decision-making
Sign Up to like & getrecommendations! Published in 2023 at "Clinical Toxicology"
DOI: 10.1080/15563650.2023.2196372
Abstract: Abstract Introduction Metformin-associated lactic acidosis is a well-described and commonly encountered condition associated with significant morbidity and mortality. Patients with metformin-associated lactic acidosis are frequently managed in the intensive care unit with supportive care, including… read more here.
Keywords: metformin associated; extracorporeal treatments; associated lactic; extracorporeal treatment ... See more keywords
Metformin is associated with a lower risk of active tuberculosis in patients with type 2 diabetes
Sign Up to like & getrecommendations! Published in 2018 at "Respirology"
DOI: 10.1111/resp.13338
Abstract: Metformin is an oral anti‐diabetic therapy (ADT) to manage type 2 diabetes mellitus (T2DM), and has been reported to have potential anti‐tuberculosis (TB) effects. This study investigates the risk of active TB among persons with… read more here.
Keywords: metformin associated; associated lower; risk active; lower risk ... See more keywords
Metformin-Associated Lactic Acidosis Undergoing Renal Replacement Therapy in Intensive Care Units: A Five-Million Population-Based Study in the North-West of Italy
Sign Up to like & getrecommendations! Published in 2017 at "Blood Purification"
DOI: 10.1159/000471917
Abstract: Background: Metformin-associated lactic acidosis (MALA) is a severe complication of drug administration with significant morbidity and mortality. So far no study in large population areas have examined the incidence, clinical profile and outcome of acute… read more here.
Keywords: metformin associated; lactic acidosis; metformin; intensive care ... See more keywords
Achieving High Dialysis Dose via Continuous Renal Replacement Therapy in the Setting of Metformin Associated Lactic Acidosis. A Case Series
Sign Up to like & getrecommendations! Published in 2022 at "A&a Practice"
DOI: 10.1213/xaa.0000000000001561
Abstract: Severe and life-threatening cases of metformin-associated lactic acidosis (MALA) are treated with renal replacement therapy. Intermittent hemodialysis is recommended, as it achieves rapid more elimination of metformin compared to continuous renal replacement therapy (CRRT). This… read more here.
Keywords: associated lactic; renal replacement; replacement therapy; metformin associated ... See more keywords
157-OR: Is Metformin Associated with Frailty in Older Veterans with Diabetes?
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes"
DOI: 10.2337/db19-157-or
Abstract: Diabetes mellitus (DM) may promote accelerated aging fostering the development of frailty, a state of vulnerability to stressors resulting in higher morbidity, mortality and healthcare utilization, particularly among Veterans. Metformin may reduce the development of… read more here.
Keywords: none; older veterans; frailty older; metformin associated ... See more keywords
Prehospital Diagnosis of Shortness of Breath Caused by Profound Metformin-Associated Metabolic Acidosis
Sign Up to like & getrecommendations! Published in 2021 at "Healthcare"
DOI: 10.3390/healthcare9010074
Abstract: Shortness of breath is a common complaint among patients in emergency medicine. While most common causes are usually promptly identified, less frequent aetiologies might be challenging to diagnose, especially in the pre-hospital setting. We report… read more here.
Keywords: metformin associated; profound metformin; shortness breath; metabolic acidosis ... See more keywords