TCTAP A-121 Metformin Attenuates High Glucose Injury by Inducing Mitophagy Through AMPK/FUNDC1 Signal Pathway in H9c2 Cells
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2017.03.163
Abstract: Mitochondrial fragmentation plays an important role in the progression of diabetic cardiomyopathy. Metformin has protective in diabetes-related cardiovascular endpoints when compared with conventional therapies. Mitophagy mediates the selective recognition and targeting of damaged mitochondria by read more here.
Keywords: attenuates high; 121 metformin; tctap 121; metformin ... See more keywords
Metformin attenuates renal tubulointerstitial fibrosis via upgrading autophagy in the early stage of diabetic nephropathy
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DOI: 10.1038/s41598-021-95827-5
Abstract: This study aimed at comparing the effects of metformin on tubulointerstitial fibrosis (TIF) in different stages of diabetic nephropathy (DN) in vivo and evaluating the mechanism in high glucose (HG)-treated renal tubular epithelial cells (RTECs)… read more here.
Keywords: fibrosis; metformin; metformin attenuates; attenuates renal ... See more keywords
Metformin Attenuates the Inflammatory Response via the Regulation of Synovial M1 Macrophage in Osteoarthritis
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DOI: 10.3390/ijms24065355
Abstract: Osteoarthritis (OA), the most common chronic inflammatory joint disease, is characterized by progressive cartilage degeneration, subchondral bone sclerosis, synovitis, and osteophyte formation. Metformin, a hypoglycemic agent used in the treatment of type 2 diabetes, has… read more here.
Keywords: attenuates inflammatory; metformin attenuates; inflammatory response; osteoarthritis ... See more keywords