Volumetric, Acoustic and Transport Properties of Metformin Hydrochloride Drug in Aqueous d-Glucose Solutions at T = (298.15–318.15) K
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DOI: 10.1007/s10953-017-0584-0
Abstract: Apparent molar volumes, apparent molar adiabatic compressibilities and viscosity B-coefficients for metformin hydrochloride in aqueous d-glucose solutions were determined from solution densities, sound velocities and viscosities measured at T = (298.15–318.15) K and at pressure p = 101 kPa as… read more here.
Keywords: molar adiabatic; metformin hydrochloride; apparent molar; 298 318 ... See more keywords
E.P.A.S.S: Electroanalytical Pillbox Assessment Sensor System, A Case Study Using Metformin Hydrochloride.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c00611
Abstract: Adulteration of medications is an emerging and significant threat to human health and well-being, even though adulterants are still often not considered seriously in clinical or forensic toxicology. Screening of drug adulterations is a major… read more here.
Keywords: electroanalytical pillbox; assessment sensor; adulteration; pillbox assessment ... See more keywords
Transdermal Cubic Phases of Metformin Hydrochloride: In Silico and in Vitro Studies of Delivery Mechanisms.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.8b00209
Abstract: Transdermal delivery is one of important controlled drug release strategies for drug development. Cubic phases are the assemblies of amphiphilic molecules in water with the hydrophilic-hydrophobic interpenetrating network for transdermal delivery of both hydrophilic and… read more here.
Keywords: transdermal delivery; cubic phases; delivery; drug ... See more keywords
Determination and Correlation of Solubility of Metformin Hydrochloride in Aqueous Binary Solvents from 283.15 to 323.15 K
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DOI: 10.1021/acsomega.1c06468
Abstract: Metformin hydrochloride (MET·HCl) is one of the most widely used oral hypoglycemic drugs in the world. In addition to hypoglycemic effects, MET·HCl also has anti-inflammatory, anti-tumor, anti-aging, and other effects, showing good efficacy and safety… read more here.
Keywords: met hcl; solubility; water; correlation ... See more keywords
Preparation and characterisation of self-emulsifying drug delivery system (SEDDS) for enhancing oral bioavailability of metformin hydrochloride using hydrophobic ion pairing complexation
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Microencapsulation"
DOI: 10.1080/02652048.2023.2170488
Abstract: Abstract Aim The aim of this study was preparation of a self-emulsifying drug delivery system (SEEDS) containing metformin hydrochloride. Methods Hydrophobic ion paired complexes were prepared by electrostatic interaction between metformin and sodium lauryl sulphate… read more here.
Keywords: self emulsifying; delivery system; emulsifying drug; drug delivery ... See more keywords
Bioequivalence and safety evaluation of two preparations of metformin hydrochloride sustained-release tablets (Boke® and Glucophage®-XR) in healthy Chinese volunteers: a randomized phase I clinical trial
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Medicine"
DOI: 10.1080/07853890.2022.2125574
Abstract: Abstract Background As per the National Medical Products Administration (NMPA) requirements, the quality and efficacy of generic drugs must be consistent with those of the innovator drug. We aimed to evaluate the bioequivalence and safety… read more here.
Keywords: glucophage; bioequivalence; bioequivalence safety; healthy chinese ... See more keywords
Metformin hydrochloride and wound healing: from nanoformulation to pharmacological evaluation
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Liposome Research"
DOI: 10.1080/08982104.2018.1556291
Abstract: Abstract Niosomes as drug delivery systems have the ability to decrease drugs' side effects and increase their therapeutic effectiveness. Metformin HCl is an oral antihyperglycemic agent belonging to biguanides. It is the most commonly chosen… read more here.
Keywords: wound healing; metformin hcl; hydrochloride wound; metformin hydrochloride ... See more keywords
DoE-based Analytical Failure Modes Critical Effect Analysis (AFMCEA) to Multipurpose-RP-HPLC Method for Estimation of Multiple FDC Products of Metformin Hydrochloride Using Analytical Quality by Design Approach.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of AOAC International"
DOI: 10.1093/jaoacint/qsac025
Abstract: BACKGROUND Metformin hydrochloride is the first choice antihyperglycemic agent and its several fixed-dose combinations (FDCs) with pioglitazone hydrochloride, sitagliptin phosphate and gliclazide are used for the management of type II diabetes. Numerous RP-HPLC and HPTLC… read more here.
Keywords: metformin hydrochloride; method; estimation; approach ... See more keywords
Metformin Hydrochloride Mucosal Nanoparticles-Based Enteric Capsule for Prolonged Intestinal Residence Time, Improved Bioavailability, and Hypoglycemic Effect
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DOI: 10.1208/s12249-022-02402-w
Abstract: Metformin hydrochloride enteric-coated capsule (MH-EC) is a commonly used clinical drug for the treatment of type 2 diabetes. In this study, we described a metformin hydrochloride mucosal nanoparticles enteric-coated capsule (MH-MNPs-EC) based on metformin hydrochloride… read more here.
Keywords: capsule; mucosal nanoparticles; metformin hydrochloride; bioavailability ... See more keywords
Analysis on the Effect of Metformin Hydrochloride Combined with Insulin Pump for Gestational Diabetes Mellitus
Sign Up to like & getrecommendations! Published in 2022 at "Iranian Journal of Public Health"
DOI: 10.18502/ijph.v51i1.8298
Abstract: Background: U To analyze the effect of metformin hydrochloride combined with insulin pump for gestational diabetes mellitus (GDM). Methods: Overall, 216 patients with GDM in Zhangqiu Maternity and Child Care Hospital, Jinan, China from Aug… read more here.
Keywords: research; combined insulin; insulin pump; group ... See more keywords
Expert design and optimization of ethyl cellulose-poly (ε-caprolactone) blend microparticles for gastro-retentive floating delivery of metformin hydrochloride.
Sign Up to like & getrecommendations! Published in 2021 at "Current drug delivery"
DOI: 10.2174/1567201818666210204164145
Abstract: BACKGROUND Metformin hydrochloride (MH) is an oral anti-hyperglycemic agent belonging to the biguanide class of drugs. OBJECTIVE The present study involves the formulation and evaluation of gastro-retentive floating microparticles containing MH as a model drug… read more here.
Keywords: retentive floating; delivery; drug; metformin hydrochloride ... See more keywords