Metformin induces human esophageal carcinoma cell pyroptosis by targeting the miR-497/PELP1 axis.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2019.02.014
Abstract: Evasion of apoptosis is a major contributing factor to the development of chemo- and radiotherapy resistance. Therefore, activation of non-apoptotic programmed cell death (PCD) could be an effective alternative against apoptosis-resistant cancers. In this study,… read more here.
Keywords: pyroptosis; targeting mir; pelp1; metformin induces ... See more keywords
Metformin induces S‐adenosylmethionine restriction to extend the Caenorhabditis elegans healthspan through H3K4me3 modifiers
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13567
Abstract: Metformin, a widely prescribed first‐line drug for the treatment of type II diabetes mellitus, has been shown to extend lifespan and delay the onset of age‐related diseases. The precisely mechanisms by which these effects are… read more here.
Keywords: adenosylmethionine restriction; caenorhabditis elegans; metformin induces; induces adenosylmethionine ... See more keywords
Metformin Induces Apoptosis and Inhibits Notch1 in Malignant Pleural Mesothelioma Cells
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2020.534499
Abstract: Malignant pleural mesothelioma (MPM) is an aggressive asbestos-related cancer arising from the mesothelial cells lining the pleural cavity. MPM is characterized by a silent clinical progression and a highly resistance to conventional chemo/radio-therapies. MPM patients… read more here.
Keywords: mpm; pleural mesothelioma; malignant pleural; metformin induces ... See more keywords