Metformin inhibits pro‐inflammatory responses via targeting nuclear factor‐κB in HaCaT cells
Sign Up to like & getrecommendations! Published in 2019 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3367
Abstract: Psoriasis is a prevalent, chronic inflammatory skin disease that arises from rapid and excessive growth of keratinocytes induced by abnormal inflammatory responses. Metformin is the first‐line drug in type 2 diabetes and has been proven… read more here.
Keywords: inflammatory responses; metformin inhibits; hacat cells; factor ... See more keywords
Metformin inhibits IL-6 signaling by decreasing IL-6R expression on multiple myeloma cells
Sign Up to like & getrecommendations! Published in 2019 at "Leukemia"
DOI: 10.1038/s41375-019-0470-4
Abstract: IL-6 signaling plays a crucial role in the pathogenesis of a number of diseases, including multiple myeloma, primary amyloidosis, cytokine release syndrome and other inflammatory conditions. It is central for the growth and survival of… read more here.
Keywords: signaling decreasing; inhibits signaling; metformin inhibits; multiple myeloma ... See more keywords
Metformin inhibits TGF‑β1‑induced epithelial‑mesenchymal transition and liver metastasis of pancreatic cancer cells.
Sign Up to like & getrecommendations! Published in 2020 at "Oncology reports"
DOI: 10.3892/or.2020.7595
Abstract: Epithelial‑mesenchymal transition (EMT) is considered a crucial event in the development of cancer metastasis. Metformin is a drug used in the treatment of type 2 diabetes. Recently, increasing evidence has indicated that metformin possesses anti‑tumor… read more here.
Keywords: metformin inhibits; pancreatic cancer; metastasis; epithelial mesenchymal ... See more keywords