Metformin prevents vascular damage in hypertension through the AMPK/ER stress pathway
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DOI: 10.1038/s41440-019-0212-z
Abstract: Metformin is an antidiabetic drug. However, the pleiotropic beneficial effects of metformin in nondiabetic models still need to be defined. The objective of this study is to investigate the effect of metformin on angiotensin II… read more here.
Keywords: metformin prevents; metformin; ampk; stress ... See more keywords
Metformin prevents hypoxia‐induced podocyte injury by regulating the ZEB2/TG2 axis
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DOI: 10.1111/nep.14121
Abstract: Podocytes, a vital component of the glomerular filtration barrier, are vulnerable to various noxious stimuli, including Hypoxic. HIF1α that transduces hypoxic adaptations induces Transglutaminase 2 (TG2), which catalyses cross‐linking of extracellular matrix proteins. In this… read more here.
Keywords: hypoxia induced; metformin prevents; induced podocyte; podocyte injury ... See more keywords