Metformin Therapy Attenuates Pro-inflammatory Microglia by Inhibiting NF-κB in Cuprizone Demyelinating Mouse Model of Multiple Sclerosis.
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DOI: 10.1007/s12640-021-00417-y
Abstract: Multiple sclerosis (MS) is a chronic disorder characterized by reactive gliosis, inflammation, and demyelination. Microglia plays a crucial role in the pathogenesis of MS and has the dynamic plasticity to polarize between pro-inflammatory (M1) and… read more here.
Keywords: metformin therapy; metformin; inflammatory; pro inflammatory ... See more keywords
In New-Onset Diabetes Mellitus, Metformin Reduces Fat Accumulation in the Liver, But Not in the Pancreas or Pericardium.
Sign Up to like & getrecommendations! Published in 2019 at "Metabolic syndrome and related disorders"
DOI: 10.1089/met.2018.0086
Abstract: Background: Nonalcoholic fatty pancreas and liver disease (NAFPD and NAFLD) and pericardial adipose tissue (PAT) are often associated with type 2 diabetes mellitus (T2DM). Our aim was to evaluate the incidence rate of NAFLD and… read more here.
Keywords: metformin therapy; control; diabetes mellitus; patients nodm ... See more keywords
Metformin therapy and cognitive dysfunction in patients with type 2 diabetes
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DOI: 10.1097/md.0000000000019378
Abstract: Abstract Background: Type 2 diabetes (T2D) is a risk factor for cognitive dysfunction. The relationship between metformin therapy and cognitive function in patients with T2D is unknown. Therefore, we determined the relationship between metformin therapy… read more here.
Keywords: metformin therapy; therapy cognitive; dysfunction; dysfunction patients ... See more keywords
Abstract P446: Hispanics/Latinos With Prediabetes are Eligible for Diabetes Prevention Intervention: Findings From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
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DOI: 10.1161/circ.141.suppl_1.p446
Abstract: Background: Hispanics/Latinos in the US are at high risk of type 2 diabetes mellitus (T2D). The American Diabetes Association (ADA) consensus statement recommends prediabetes screening in persons with body mass index (BMI) ≥ 25 kg/m… read more here.
Keywords: metformin therapy; heritage; american heritage; study ... See more keywords
Baseline gut microbiome composition predicts metformin therapy short-term efficacy in newly diagnosed type 2 diabetes patients
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DOI: 10.1371/journal.pone.0241338
Abstract: Background The study was conducted to investigate the effects of metformin treatment on the human gut microbiome’s taxonomic and functional profile in the Latvian population, and to evaluate the correlation of these changes with therapeutic… read more here.
Keywords: metformin therapy; newly diagnosed; efficacy; gut microbiome ... See more keywords
Metformin therapy and the risk of colorectal adenoma in patients with type 2 diabetes: A meta-analysis
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DOI: 10.18632/oncotarget.13633
Abstract: Background Existing data evaluating the impact of metformin on the colorectal adenoma (CRA) risk in patients suffering from type 2 diabetes (T2D) are limited and controversial. We therefore summarized the studies currently available and assessed… read more here.
Keywords: metformin therapy; risk; analysis; type diabetes ... See more keywords
Association between metformin and the risk of gastric cancer in patients with type 2 diabetes mellitus: a meta-analysis of cohort studies.
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DOI: 10.18632/oncotarget.16973
Abstract: OBJECTIVES The objective of this study was to evaluate the association between metformin therapy and the incidence of gastric cancer (GC) in patients with type 2 diabetes mellitus (T2DM). METHODS We systemically searched the following… read more here.
Keywords: metformin therapy; risk; analysis; metformin ... See more keywords
Efficacy of Metformin for Benign Thyroid Nodules in Subjects With Insulin Resistance: A Systematic Review and Meta-Analysis
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DOI: 10.3389/fendo.2018.00494
Abstract: Background: To evaluate the effect of metformin therapy on decreasing benign thyroid nodule volume in subjects with insulin resistance (IR). Method: Randomized controlled trials (RCTs) and self-controlled trials for the meta-analysis published, before January 31,… read more here.
Keywords: metformin therapy; analysis; benign thyroid; meta analysis ... See more keywords
Genetic and Phenotypic Factors Affecting Glycemic Response to Metformin Therapy in Patients with Type 2 Diabetes Mellitus
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DOI: 10.3390/genes13081310
Abstract: Metformin is an oral hypoglycemic agent widely used in clinical practice for treatment of patients with type 2 diabetes mellitus (T2DM). The wide interindividual variability of response to metformin therapy was shown, and recently the… read more here.
Keywords: response metformin; metformin therapy; response; type diabetes ... See more keywords
Effect of high-fat diet-induced obesity on thyroid gland structure in female rats and the possible ameliorating effect of metformin therapy.
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DOI: 10.5603/fm.a2019.0100
Abstract: BACKGROUND Obesity is known to induce a state of lipotoxicity that affects the different organs of the body. Metformin is an antidiabetic drug commonly used in obesity treatment. It was known to improve thyroid function… read more here.
Keywords: metformin therapy; obesity; thyroid; thyroid gland ... See more keywords