Insights from yeast: Transcriptional reprogramming following metformin treatment is similar to that of deferiprone in a yeast Friedreich's ataxia model
Sign Up to like & getrecommendations! Published in 2023 at "Yeast"
DOI: 10.1002/yea.3845
Abstract: In the absence of YFH1, the yeast ortholog of the human FXN gene, budding yeast Saccharomyces cerevisiae experience similar problems to those of cells with Friedreich's ataxia (FRDA). The comparable phenotypic traits consist of impaired… read more here.
Keywords: friedreich ataxia; yeast; model; treatment ... See more keywords
The anti-periodontitis action of metformin via targeting NLRP3 inflammasome.
Sign Up to like & getrecommendations! Published in 2020 at "Archives of oral biology"
DOI: 10.1016/j.archoralbio.2020.104692
Abstract: OBJECTIVE Periodontitis is one of the most prevalent chronic inflammatory diseases causing tooth loss in patients. However, effective ways to treat periodontitis are still limited. Metformin has been suggested to have anti-inflammatory effects in the… read more here.
Keywords: nlrp3 inflammasome; metformin treatment; metformin; periodontitis ... See more keywords
Metformin treatment does not affect the risk of ruptured abdominal aortic aneurysms
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Vascular Surgery"
DOI: 10.1016/j.jvs.2017.01.070
Abstract: Objective: Diabetes counteracts formation and rupture of abdominal aortic aneurysms, possibly through arterial matrix accumulation. Use of metformin, on the other hand, reduces arterial accumulation of matrix molecules. Consequently, we hypothesized that metformin treatment may… read more here.
Keywords: risk; ruptured abdominal; metformin; aortic aneurysms ... See more keywords
Corrigendum: Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota
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DOI: 10.1038/nature22318
Abstract: This corrects the article DOI: 10.1038/nature15766 read more here.
Keywords: corrigendum disentangling; treatment signatures; disentangling type; type diabetes ... See more keywords
Metformin prevents vascular damage in hypertension through the AMPK/ER stress pathway
Sign Up to like & getrecommendations! Published in 2019 at "Hypertension Research"
DOI: 10.1038/s41440-019-0212-z
Abstract: Metformin is an antidiabetic drug. However, the pleiotropic beneficial effects of metformin in nondiabetic models still need to be defined. The objective of this study is to investigate the effect of metformin on angiotensin II… read more here.
Keywords: metformin prevents; metformin; ampk; stress ... See more keywords
Metformin treatment for 8 days impacts multiple intestinal parameters in high-fat high-sucrose fed mice
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DOI: 10.1038/s41598-021-95117-0
Abstract: Although the mechanism of action of the antidiabetic drug metformin is still a matter of discussions, it is well accepted that the gut plays an important role. To gain more insights into the mechanisms occurring… read more here.
Keywords: hfs diet; high sucrose; fat high; high fat ... See more keywords
Cost-effectiveness analysis of dapagliflozin treatment versus metformin treatment in Chinese population with type 2 diabetes
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DOI: 10.1080/13696998.2019.1570220
Abstract: Abstract Background and objective: Dapagliflozin is the first SGLT2 inhibitor available in China, where the disease burden of diabetes and its complications is very heavy. Because a new diabetes treatment strategy for diabetes should consider… read more here.
Keywords: treatment; cost; cost effectiveness; metformin treatment ... See more keywords
Spatial variation of the gut microbiome in response to long-term metformin treatment in high-fat diet-induced type 2 diabetes mouse model of both sexes
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DOI: 10.1080/19490976.2023.2188663
Abstract: ABSTRACT Antidiabetic drug metformin alters the gut microbiome composition in the context of type 2 diabetes and other diseases; however, its effects have been mainly studied using fecal samples, which offer limited information about the… read more here.
Keywords: spatial variation; type diabetes; metformin treatment; gut microbiome ... See more keywords
Metformin Alleviates Altered Erythrocyte Redox Status During Aging in Rats.
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DOI: 10.1089/rej.2016.1826
Abstract: Metformin, a biguanide drug commonly used to treat type 2 diabetes, has been noted to function as a caloric restriction mimetic. Its antidiabetic effect notwithstanding, metformin is currently being considered an antiaging drug candidate, although… read more here.
Keywords: status; plasma; age; treatment ... See more keywords
P–284 Changes in protein expression due to metformin treatment and hyperinsulinemia in a human endometrial cancer cell line
Sign Up to like & getrecommendations! Published in 2021 at "Human Reproduction"
DOI: 10.1093/humrep/deab130.283
Abstract: The aim of the study was to identify new target proteins/pathways that are affected by metformin treatment in endometrial cancer cells in a proteomic approach. The expression of 1,300 different proteins were investigated, of which… read more here.
Keywords: protein expression; treatment; endometrial cancer; cancer ... See more keywords
The effect of metformin treatment on the basal and gonadotropin‐stimulated steroidogenesis in male rats with type 2 diabetes mellitus
Sign Up to like & getrecommendations! Published in 2020 at "Andrologia"
DOI: 10.1111/and.13816
Abstract: Type 2 diabetes mellitus impairs reproductive functions in men, and important tasks are deciphering the mechanisms of testicular dysfunctions in diabetes and the search of effective approaches to their correction. The purpose was to study… read more here.
Keywords: gonadotropin; leptin; type diabetes; basal gonadotropin ... See more keywords