Adolescent methamphetamine exposure drives neuroinflammation and aberrant neurogenesis linked to anxiety and cognitive impairments in adult mice
Sign Up to like & getrecommendations! Published in 2025 at "Translational Psychiatry"
DOI: 10.1038/s41398-025-03613-y
Abstract: The adolescent brain, characterized by its high plasticity, is particularly vulnerable to substance abuse, leading to long-term impacts on brain function and behavior. Methamphetamine (METH), a potent psychostimulant, is associated with severe neurological and psychiatric… read more here.
Keywords: neuroinflammation; methamphetamine; adolescent meth; adulthood ... See more keywords
Activation of proline biosynthesis is critical to maintain glutamate homeostasis during acute methamphetamine exposure
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DOI: 10.1038/s41598-020-80917-7
Abstract: Methamphetamine (METH) is a highly addictive psychostimulant that causes long-lasting effects in the brain and increases the risk of developing neurodegenerative diseases. The cellular and molecular effects of METH in the brain are functionally linked… read more here.
Keywords: glutamate levels; meth exposure; glutamate homeostasis; exposure ... See more keywords
Timing of Methamphetamine Exposure during Adolescence Differentially Influences Parvalbumin and Perineuronal Net Immunoreactivity in the Medial Prefrontal Cortex of Female, but Not Male, Rats
Sign Up to like & getrecommendations! Published in 2024 at "Developmental Neuroscience"
DOI: 10.1159/000538608
Abstract: Adolescence involves significant reorganization within the medial prefrontal cortex (mPFC), including modifications to inhibitory neurotransmission mediated through parvalbumin (PV) interneurons and their surrounding perineuronal nets (PNNs). These developmental changes, which result in increased PV neuron… read more here.
Keywords: adolescence; medial prefrontal; prefrontal cortex; meth exposure ... See more keywords
The Adverse Effects of Prenatal METH Exposure on the Offspring: A Review
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.715176
Abstract: Abuse of methamphetamine (METH), an illicit psychostimulant, is a growing public health issue. METH abuse during pregnancy is on the rise due to its stimulant, anorectic, and hallucinogenic properties. METH can lead to multiple organ… read more here.
Keywords: effects prenatal; meth exposure; prenatal meth; toxicity ... See more keywords
Maternal Methamphetamine Exposure Influences Behavioral Sensitization and Nucleus Accumbens DNA Methylation in Subsequent Generation
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DOI: 10.3389/fphar.2022.940798
Abstract: The deleterious effects of methamphetamine (METH) exposure extend beyond abusers, and may potentially impact the vulnerability of their offspring in developing addictive behaviors. Epigenetic signatures have been implicated in addiction, yet the characteristics to identify… read more here.
Keywords: meth exposure; meth; behavioral sensitization; exposure ... See more keywords
Decreasing β-Catenin Leads to Altered Endothelial Morphology, Increased Barrier Permeability and Cognitive Impairment During Chronic Methamphetamine Exposure
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms26041514
Abstract: Cognitive impairment induced by chronic methamphetamine (METH) exposure exhibits similarities to neurodegenerative disorders and is associated with blood–brain barrier (BBB) dysfunction. However, the potential involvement of β-catenin in maintaining BBB integrity during METH exposure remains… read more here.
Keywords: cognitive impairment; catenin; meth exposure; exposure ... See more keywords