Differential perturbations of gut microbial profiles and co-occurrence networks among phases of methamphetamine-induced conditioned place preference.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of neuroscience research"
DOI: 10.1002/jnr.24963
Abstract: The gut-brain axis provides a pathway for the interaction between gut microbiota and methamphetamine (METH) addiction. However, the gut microbial signatures during different phases of METH use remain unclear. In the present study, we established… read more here.
Keywords: phases meth; conditioned place; among phases; induced conditioned ... See more keywords
Inflammasome Activation by Methamphetamine Potentiates Lipopolysaccharide Stimulation of IL-1β Production in Microglia
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuroimmune Pharmacology"
DOI: 10.1007/s11481-018-9780-y
Abstract: Methamphetamine (Meth) is an addictive psychostimulant abused worldwide. Ample evidence indicate that chronic abuse of Meth induces neurotoxicity via microglia-associated neuroinflammation and the activated microglia present in both Meth-administered animals and human abusers. The development… read more here.
Keywords: production; inflammasome activation; methamphetamine; meth induced ... See more keywords
Effect of PPM1F in dorsal raphe 5-HT neurons in regulating methamphetamine-induced conditioned place preference performance in mice
Sign Up to like & getrecommendations! Published in 2022 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2021.12.001
Abstract: Methamphetamine (METH), a synthetically produced central nervous system stimulant, is one of the most illicit and addictive drugs worldwide. Protein phosphatase Mg2+/Mn2+-dependent 1F (PPM1F) has been reported to exert multiple biological and cellular functions. Nevertheless,… read more here.
Keywords: drn; ppm1f; induced conditioned; conditioned place ... See more keywords
Ginsenoside Rb1 attenuates methamphetamine (METH)-induced neurotoxicity through the NR2B/ERK/CREB/BDNF signalings in vitro and in vivo models
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Ginseng Research"
DOI: 10.1016/j.jgr.2021.07.005
Abstract: Abstract Aim This study investigates the effects of ginsenoside Rb1 (GsRb1) on methamphetamine (METH)-induced toxicity in SH-SY5Y neuroblastoma cells and METH-induced conditioned place preference (CPP) in adult Sprague-Dawley rats. It also examines whether GsRb1 can… read more here.
Keywords: nr2b erk; erk creb; creb bdnf; creb ... See more keywords
Cannabidiol enhanced the development of sensitization to the expression of methamphetamine-induced conditioned place preference in male rats.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of psychiatric research"
DOI: 10.1016/j.jpsychires.2021.02.045
Abstract: Cannabis and ecstasy are illicit substances, and currently, there are no approved treatments for methamphetamine (METH) use disorder. Some studies have proposed that cannabidiol (CBD) decreases the motivation for METH seeking, but reports indicate that… read more here.
Keywords: conditioned place; cbd; place preference; meth induced ... See more keywords
GKT136901 protects primary human brain microvascular endothelial cells against methamphetamine-induced blood-brain barrier dysfunction.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.117917
Abstract: AIMS Methamphetamine (METH) is an abused psychostimulant causing public health concern worldwide. While most studies have focused on the neurotoxic effects of METH, METH-induced cerebrovascular dysfunction has recently drawn attention as an important facet of… read more here.
Keywords: blood brain; dysfunction; induced blood; meth induced ... See more keywords
Melatonin reverts methamphetamine-induced learning and memory impairments and hippocampal alterations in mice.
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DOI: 10.1016/j.lfs.2020.118844
Abstract: AIMS Methamphetamine (METH) has become a major public health problem because of its abuse and profound neurotoxic effects, causing alterations in brain structure and function, and impairing cognitive functions, including attention, decision making, emotional memory,… read more here.
Keywords: bdnf nmda; learning memory; meth induced; mel ... See more keywords
Upregulation of CCL7 and CCL2 in reward system mediated through dopamine D1 receptor signaling underlies methamphetamine-induced place preference in mice
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2017.11.042
Abstract: We previously showed that the CC-chemokine ligand 2 (CCL2)-CC-chemokine receptor 2 (CCR2) system is responsible for conditioned place preference (CPP) by methamphetamine (Meth). In this study, we investigated the roles for other chemokines mediating Meth-induced… read more here.
Keywords: receptor; ccl7 ccl2; place preference; meth induced ... See more keywords
M100907 and BD 1047 attenuate the acute toxic effects of methamphetamine.
Sign Up to like & getrecommendations! Published in 2019 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2019.05.011
Abstract: There are no Food and Drug Administration approved pharmacotherapies for methamphetamine (METH) overdose, thus identifying novel drug targets to prevent this devastating adverse event is a public-health imperative. Previous research suggests that serotonin and sigma… read more here.
Keywords: m100907; meth induced; meth overdose; reduced meth ... See more keywords
Regulation of microRNA-29c in the nucleus accumbens modulates methamphetamine -induced locomotor sensitization in mice
Sign Up to like & getrecommendations! Published in 2019 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2019.01.007
Abstract: ABSTRACT Changes in microRNA (miRNA)‐mediated gene expression in the nucleus accumbens (NAc) may play important roles in regulating drug addiction. MiR‐29c is a highly expressed miRNA in the human and rodent nervous systems where it… read more here.
Keywords: induced locomotor; meth induced; expression; locomotor sensitization ... See more keywords
Melatonin ameliorates methamphetamine-induced cognitive impairments by inhibiting neuroinflammation via suppression of the TLR4/MyD88/NFκB signaling pathway in the mouse hippocampus
Sign Up to like & getrecommendations! Published in 2021 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2020.110109
Abstract: Methamphetamine (METH) is a highly addictive psychostimulant that causes significant health issues due to high prevalence of its illegal use. Chronic use of METH is associated with cognitive impairments in both human and animal studies,… read more here.
Keywords: tlr4 myd88; cognitive impairments; mouse hippocampus; induced cognitive ... See more keywords