Interactions of dimethylaminoethyl methacrylate copolymer with non‐acidic drugs demonstrated high solubilization in vitro and pronounced sustained release in vivo
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2018.01.006
Abstract: Graphical abstract Figure. No caption available. ABSTRACT Recent work demonstrated remarkable solubilization effects of methacrylate‐copolymer Eudragit EPO (EPO) not only with acidic drugs but interestingly also with poorly soluble basic compounds. The current work studied… read more here.
Keywords: vivo; methacrylate copolymer; solubilization; acidic drugs ... See more keywords
Unexpected Solubility Enhancement of Drug Bases in the Presence of a Dimethylaminoethyl Methacrylate Copolymer.
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DOI: 10.1021/acs.molpharmaceut.7b00804
Abstract: The methacrylate copolymer Eudragit EPO (EPO) has previously shown to greatly enhance solubilization of acidic drugs via ionic interactions and by multiple hydrophobic contacts with polymeric side chains. The latter type of interaction could also… read more here.
Keywords: presence; methacrylate copolymer; drug; solubility enhancement ... See more keywords
Methacrylate-copolymer Eudragit EPO as solubility-enabling excipient for anionic drugs: Investigation of drug solubility, intestinal permeability, and their interplay.
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DOI: 10.1021/acs.molpharmaceut.9b00057
Abstract: The purpose of this work was to investigate the use of the dimethylaminoethyl methacrylate-copolymer Eudragit EPO (EPO) in oral solubility- enabling formulations for anionic lipophilic drugs, aiming to guide optional formulation design, and maximize oral… read more here.
Keywords: solubility enabling; methacrylate copolymer; permeability; drug ... See more keywords