First Trimester Use of Buprenorphine or Methadone and the Risk of Congenital Malformations.
Sign Up to like & getrecommendations! Published in 2024 at "JAMA internal medicine"
DOI: 10.1001/jamainternmed.2023.6986
Abstract: Importance Use of buprenorphine or methadone to treat opioid use disorder is recommended in pregnancy; however, their teratogenic potential is largely unknown. Objective To compare the risk of congenital malformations following in utero exposure to… read more here.
Keywords: risk; use buprenorphine; buprenorphine methadone; methadone ... See more keywords
Medicare Beneficiary Receipt of Methadone by Drive Time to Opioid Treatment Programs
Sign Up to like & getrecommendations! Published in 2025 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2025.3099
Abstract: Key Points Question What is the association of opioid treatment program availability with dispensation of methadone, a medication for opioid use disorder, for Medicare beneficiaries with a recent diagnosis of opioid use disorder? Findings In… read more here.
Keywords: drive time; treatment; treatment programs; opioid treatment ... See more keywords
Pharmacokinetic Effects of Isavuconazole Coadministration With the Cytochrome P450 Enzyme Substrates Bupropion, Repaglinide, Caffeine, Dextromethorphan, and Methadone in Healthy Subjects
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.281
Abstract: This report describes phase 1 clinical trials performed to assess interactions of oral isavuconazole at the clinically targeted dose (200 mg, administered as isavuconazonium sulfate 372 mg, 3 times a day for 2 days; 200… read more here.
Keywords: auc reduced; methadone; auc; substrates bupropion ... See more keywords
Current Concepts in Methadone Metabolism and Transport
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.326
Abstract: Methadone is a cornerstone therapy for opioid addiction and a public health strategy for HIV/AIDS and hepatitis C reduction. Methadone is also used for acute and chronic pain. As use for chronic pain has grown,… read more here.
Keywords: genetics; methadone; drug; methadone disposition ... See more keywords
Evaluation of the Pharmacokinetic Interaction Between Doravirine and Methadone
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.699
Abstract: Doravirine is a novel nonnucleoside reverse transcriptase inhibitor indicated for the treatment of HIV type 1 infection. A subset of people living with HIV receives methadone for the treatment of opioid addiction. The current study… read more here.
Keywords: doravirine; plasma concentration; doravirine methadone; methadone ... See more keywords
Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2B6 Genotype and Methadone Therapy
Sign Up to like & getrecommendations! Published in 2024 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.3338
Abstract: Methadone is a mu (μ) opioid receptor agonist used clinically in adults and children to manage opioid use disorder, neonatal abstinence syndrome, and acute and chronic pain. It is typically marketed as a racemic mixture… read more here.
Keywords: pharmacogenetics implementation; clinical pharmacogenetics; methadone; cyp2b6 ... See more keywords
Quantitative determination of R/S-methadone in human serum using ultra-high performance supercritical fluid chromatography-tandem mass spectrometry: A method for routine use.
Sign Up to like & getrecommendations! Published in 2024 at "Drug testing and analysis"
DOI: 10.1002/dta.3693
Abstract: Methadone has two enantiomers, which exhibit differences in pharmacological effects, with R-methadone being the active and S-methadone the inactive enantiomer. A robust, simple and rapid method for chiral separation of the two enantiomers in serum… read more here.
Keywords: method; performance supercritical; high performance; using ultra ... See more keywords
Enantioselective capillary electrophoresis for pharmacokinetic analysis of methadone and 2‐ethylidene‐1,5‐dimethyl‐3,3‐diphenylpyrrolidine in equines anesthetized with ketamine and isoflurane
Sign Up to like & getrecommendations! Published in 2019 at "ELECTROPHORESIS"
DOI: 10.1002/elps.201900044
Abstract: An enantioselective assay for the determination of methadone and its main metabolite 2‐ethylidene‐1,5‐dimethyl‐3,3‐diphenylpyrrolidine in equine plasma based on capillary electrophoresis with highly sulfated γ‐cyclodextrin as chiral selector and electrokinetic analyte injection is described. The assay… read more here.
Keywords: ethylidene dimethyl; capillary electrophoresis; dimethyl diphenylpyrrolidine; methadone ... See more keywords
Comparative evaluation of the sedative and physiological effects of medetomidine alone and in combination with pethidine, morphine, tramadol, and methadone in goats
Sign Up to like & getrecommendations! Published in 2022 at "Veterinary Medicine and Science"
DOI: 10.1002/vms3.806
Abstract: Abstract Background The use of combinations of α2‐adrenergic agonists and opioids has been published as providing superior sedation than either drug alone. Introduction The present study aims to compare the sedative and physiological effects of… read more here.
Keywords: morphine; medetomidine; combination; methadone ... See more keywords
Switchable Hydrophilicity Solvent-Based Homogenous Liquid–Liquid Microextraction (SHS-HLLME) Combined with GC-FID for the Quantification of Methadone and Tramadol
Sign Up to like & getrecommendations! Published in 2018 at "Chromatographia"
DOI: 10.1007/s10337-018-3528-y
Abstract: In this work, a new method based on homogeneous liquid-phase microextraction was developed for the determination of methadone and tramadol. Dipropylamine was used as extraction solvent with switchable hydrophilicity that can be miscible/immiscible upon the… read more here.
Keywords: methadone tramadol; switchable hydrophilicity; phase; liquid ... See more keywords
Chiral separation of methadone using solid membrane extraction based on chiral selector, solid membrane: sheep skin leather
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Iranian Chemical Society"
DOI: 10.1007/s13738-019-01634-1
Abstract: A new, green, and without solvent extraction method and chiral separation system effective in separation of racemic methadone is presented. We have used sheep leather as the membrane in enantioselective extraction for chiral separation of… read more here.
Keywords: chiral selector; methadone; separation; membrane ... See more keywords