Pharmacokinetic Effects of Isavuconazole Coadministration With the Cytochrome P450 Enzyme Substrates Bupropion, Repaglinide, Caffeine, Dextromethorphan, and Methadone in Healthy Subjects
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.281
Abstract: This report describes phase 1 clinical trials performed to assess interactions of oral isavuconazole at the clinically targeted dose (200 mg, administered as isavuconazonium sulfate 372 mg, 3 times a day for 2 days; 200… read more here.
Keywords: auc reduced; methadone; auc; substrates bupropion ... See more keywords
Current Concepts in Methadone Metabolism and Transport
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DOI: 10.1002/cpdd.326
Abstract: Methadone is a cornerstone therapy for opioid addiction and a public health strategy for HIV/AIDS and hepatitis C reduction. Methadone is also used for acute and chronic pain. As use for chronic pain has grown,… read more here.
Keywords: genetics; methadone; drug; methadone disposition ... See more keywords
Evaluation of the Pharmacokinetic Interaction Between Doravirine and Methadone
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.699
Abstract: Doravirine is a novel nonnucleoside reverse transcriptase inhibitor indicated for the treatment of HIV type 1 infection. A subset of people living with HIV receives methadone for the treatment of opioid addiction. The current study… read more here.
Keywords: doravirine; plasma concentration; doravirine methadone; methadone ... See more keywords
Enantioselective capillary electrophoresis for pharmacokinetic analysis of methadone and 2‐ethylidene‐1,5‐dimethyl‐3,3‐diphenylpyrrolidine in equines anesthetized with ketamine and isoflurane
Sign Up to like & getrecommendations! Published in 2019 at "ELECTROPHORESIS"
DOI: 10.1002/elps.201900044
Abstract: An enantioselective assay for the determination of methadone and its main metabolite 2‐ethylidene‐1,5‐dimethyl‐3,3‐diphenylpyrrolidine in equine plasma based on capillary electrophoresis with highly sulfated γ‐cyclodextrin as chiral selector and electrokinetic analyte injection is described. The assay… read more here.
Keywords: ethylidene dimethyl; capillary electrophoresis; dimethyl diphenylpyrrolidine; methadone ... See more keywords
Comparative evaluation of the sedative and physiological effects of medetomidine alone and in combination with pethidine, morphine, tramadol, and methadone in goats
Sign Up to like & getrecommendations! Published in 2022 at "Veterinary Medicine and Science"
DOI: 10.1002/vms3.806
Abstract: Abstract Background The use of combinations of α2‐adrenergic agonists and opioids has been published as providing superior sedation than either drug alone. Introduction The present study aims to compare the sedative and physiological effects of… read more here.
Keywords: morphine; medetomidine; combination; methadone ... See more keywords
Switchable Hydrophilicity Solvent-Based Homogenous Liquid–Liquid Microextraction (SHS-HLLME) Combined with GC-FID for the Quantification of Methadone and Tramadol
Sign Up to like & getrecommendations! Published in 2018 at "Chromatographia"
DOI: 10.1007/s10337-018-3528-y
Abstract: In this work, a new method based on homogeneous liquid-phase microextraction was developed for the determination of methadone and tramadol. Dipropylamine was used as extraction solvent with switchable hydrophilicity that can be miscible/immiscible upon the… read more here.
Keywords: methadone tramadol; switchable hydrophilicity; phase; liquid ... See more keywords
Chiral separation of methadone using solid membrane extraction based on chiral selector, solid membrane: sheep skin leather
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Iranian Chemical Society"
DOI: 10.1007/s13738-019-01634-1
Abstract: A new, green, and without solvent extraction method and chiral separation system effective in separation of racemic methadone is presented. We have used sheep leather as the membrane in enantioselective extraction for chiral separation of… read more here.
Keywords: chiral selector; methadone; separation; membrane ... See more keywords
Methadone for Pain Management: A Pharmacotherapeutic Review
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DOI: 10.1007/s40263-020-00743-3
Abstract: Methadone is increasingly being used for its analgesic properties. Despite the increasing popularity, many healthcare providers are not familiar with methadone’s complex pharmacology and best practices surrounding its use. The purpose of this narrative review… read more here.
Keywords: use; pain management; methadone; pharmacology ... See more keywords
Impact of rooming‐in and breastfeeding on neonatal opioid withdrawal: A cost‐effective analysis: 315
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DOI: 10.1016/j.ajog.2018.11.336
Abstract: standard statistics were used with a p value of read more here.
Keywords: use; impact rooming; methadone; 178 methadone ... See more keywords
Methamphetamine dependence in methadone treatment services in Iran: the first literature review of a new health concern.
Sign Up to like & getrecommendations! Published in 2018 at "Asian journal of psychiatry"
DOI: 10.1016/j.ajp.2018.01.001
Abstract: BACKGROUND Methamphetamine dependence is a serious health problem among Iranian methadone patients. AIM The current study is the first research that reviewed the prevalence of methamphetamine dependence and the associated harms among Iranian methadone patients.… read more here.
Keywords: methamphetamine dependence; dependence; treatment; methadone ... See more keywords
The OPTIMA study, buprenorphine/naloxone and methadone models of care for the treatment of prescription opioid use disorder: Study design and rationale.
Sign Up to like & getrecommendations! Published in 2018 at "Contemporary clinical trials"
DOI: 10.1016/j.cct.2018.04.001
Abstract: BACKGROUND Rates of non-medical use of opioids, and opioid use disorders (OUD) have been rising throughout North America. Methadone and buprenorphine/naloxone are the recommended first-line treatment options for OUD in Canada. Most studies to date… read more here.
Keywords: buprenorphine naloxone; treatment; opioid use; study ... See more keywords