Combined effects of quetiapine and opioids: A study of autopsy cases, drug users and sedation in rats
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DOI: 10.1111/adb.13214
Abstract: Fatal opioid poisonings often involve methadone or morphine. This study aimed to elucidate if quetiapine, a widely used sedative antipsychotic medication, may increase the risk of fatal opioid poisoning by additive inhibitory effects on the… read more here.
Keywords: combined effects; methadone morphine; drug users; fatal opioid ... See more keywords
Epidural methadone and morphine pharmacokinetics and clinical effects in healthy volunteers: A randomized, crossover‐design trial
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DOI: 10.1111/bcp.16178
Abstract: Epidural opioids can provide effective analgesia for acute postoperative pain. Due to its unique physicochemical properties and long systemic elimination half‐life, epidural methadone may provide lasting analgesia with minimal adverse effects; however, human studies are… read more here.
Keywords: methadone morphine; epidural methadone; pharmacokinetics clinical; methadone ... See more keywords