Enantioselective [6 + 2]-Cycloaddition of Transient 3-Methide-3H-pyrroles with 2-Vinylindoles under Chiral Brønsted Acid Catalysis.
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DOI: 10.1021/acs.orglett.2c02548
Abstract: An organocatalytic, highly diastereo- and enantioselective [6 + 2]-cycloaddition of 3-methide-3H-pyrroles with 2-vinylindoles has been developed. This BINOL phosphoric acid-catalyzed reaction utilizes pyrrole-3-carbinols as precursors for the in situ generation of 3-methide-3H-pyrroles to access densely… read more here.
Keywords: enantioselective cycloaddition; methide; acid; methide pyrroles ... See more keywords