Mammalian Esterase Activity: Implications for Peptide Prodrugs.
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DOI: 10.1021/acs.biochem.4c00446
Abstract: As a traceless, bioreversible modification, the esterification of carboxyl groups in peptides and proteins has the potential to increase their clinical utility. An impediment is the lack of strategies to quantify esterase-catalyzed hydrolysis rates for… read more here.
Keywords: quinone methide; esterase; esterase activity; methide elimination ... See more keywords