Reversion of methionine addiction of osteosarcoma cells to methionine independence results in loss of malignancy, modulation of the epithelial-mesenchymal phenotype and alteration of histone-H3 lysine-methylation
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DOI: 10.3389/fonc.2022.1009548
Abstract: Methionine addiction, a fundamental and general hallmark of cancer, known as the Hoffman Effect, is due to altered use of methionine for increased and aberrant transmethylation reactions. However, the linkage of methionine addiction and malignancy… read more here.
Keywords: methylation; malignancy; methionine; 143b cells ... See more keywords
Glioblastoma and Methionine Addiction
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DOI: 10.3390/ijms23137156
Abstract: Glioblastoma is a fatal brain tumor with a bleak prognosis. The use of chemotherapy, primarily the alkylating agent temozolomide, coupled with radiation and surgical resection, has provided some benefit. Despite this multipronged approach, average patient… read more here.
Keywords: glioblastoma methionine; glioblastoma; methionine; tumor ... See more keywords