Methionine cycle in nonalcoholic fatty liver disease and its potential applications.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2022.115033
Abstract: As a chronic metabolic disease affecting epidemic proportions worldwide, the pathogenesis of Nonalcoholic Fatty Liver Disease (NAFLD) is not clear yet. There is also a lack of precise biomarkers and specific medicine for the diagnosis… read more here.
Keywords: cycle; methionine cycle; fatty liver; disease ... See more keywords
The interplay between nuclear and cytoplasmic distribution of methionine cycle enzymes in acute liver injury
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.04.275
Abstract: The hepatic methionine cycle comprises specific isoenzymes and proteins classically ascribed to the cytoplasm, with metabolites being putatively transported to other subcellular locations as required. This hypothesis was challenged by the identification of several enzymes… read more here.
Keywords: nuclear cytoplasmic; acute liver; cycle; methionine cycle ... See more keywords
Extracellular Matrix Microstructures Modulate Hepatic Methionine Cycle and Methylations.
Sign Up to like & getrecommendations! Published in 2025 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.4c01748
Abstract: The field of mechanobiology has grown in the past decade, but limited studies investigate how the extracellular matrix affects the cell metabolome. The methionine cycle involves the catabolism and regeneration of methionine through the donation… read more here.
Keywords: extracellular matrix; cycle; matrix microstructures; methionine cycle ... See more keywords
TMET-36. INCREASED METHIONINE CYCLE DRIVES PYRIMIDINE METABOLISM IN LETHAL PEDIATRIC EPENDYMOMAS
Sign Up to like & getrecommendations! Published in 2024 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noae165.1174
Abstract: Supratentorial ependymomas (ST-EPN) are pediatric brain tumors found in the cerebral hemisphere, driven by the oncogenic fusion of ZFTA with RELA. Other than surgery and radiotherapy, these tumors do not have effective therapeutic options. Recurrent… read more here.
Keywords: tmet increased; pyrimidine metabolism; methionine cycle; metabolism ... See more keywords
Disruption of the methionine cycle and reduced cellular gluthathione levels underlie potex-potyvirus synergism in Nicotiana benthamiana.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular plant pathology"
DOI: 10.1111/mpp.12661
Abstract: Infection caused by the synergistic interaction of two plant viruses is typically manifested by severe symptoms and increased accumulation of either virus. In potex-potyviral synergism, the potyviral RNA silencing suppressor helper component proteinase (HCPro) is… read more here.
Keywords: methionine cycle; potex potyvirus; expression; nicotiana benthamiana ... See more keywords
SAT-658 Implications of Estrogen-SAM-m6A axis in MASLD progression
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the Endocrine Society"
DOI: 10.1210/jendso/bvaf149.093
Abstract: Abstract Disclosure: S. Krylova: None. A. Landgraf: None. S. Sidoli: None. J. Pessin: None. It is well known that premenopausal females are relatively protected against metabolic dysfunction-associated steatotic liver disease (MASLD) compared to postmenopausal females… read more here.
Keywords: m6a; methylation; methionine cycle; masld ... See more keywords
Methionine Cycle Rewiring by Targeting miR-873-5p Modulates Ammonia Metabolism to Protect the Liver from Acetaminophen
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11050897
Abstract: Drug-induced liver injury (DILI) development is commonly associated with acetaminophen (APAP) overdose, where glutathione scavenging leads to mitochondrial dysfunction and hepatocyte death. DILI is a severe disorder without effective late-stage treatment, since N-acetyl cysteine must… read more here.
Keywords: cycle; liver; methionine cycle; mitochondrial dysfunction ... See more keywords
Folate–Methionine Cycle Disruptions in ASD Patients and Possible Interventions: A Systematic Review
Sign Up to like & getrecommendations! Published in 2023 at "Genes"
DOI: 10.3390/genes14030709
Abstract: Autism Spectrum Disorder (ASD) has become a major public health concern due to its rapidly rising incidence over the past few years. Disturbances in folate or methionine metabolism have been identified in many individuals with… read more here.
Keywords: folate methionine; cycle; methionine cycle; systematic review ... See more keywords