Post-Assembly Modification of Head-to-Tail Cyclic Peptides by Methionine-Directed β-C(sp3)-H Arylation.
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DOI: 10.1021/acs.orglett.2c02253
Abstract: Peptide modification by C(sp3)-H functionalization of internal residues remains a major challenge due to the inhibitory effect of peptide bonds. In this work, we developed a methionine-directed β-C(sp3)-H arylation method for internal alanine functionalization. By… read more here.
Keywords: methionine directed; directed sp3; head; head tail ... See more keywords
Late-Stage Glycosylation of Peptides by Methionine-Directed β-C(sp3)-H Functionalization with 1-Iodoglycals.
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DOI: 10.1021/acs.orglett.4c02392
Abstract: Using l-methionine (Met) as the endogenous directing group, we developed Pd-catalyzed β-C(sp3)-H glycosylation of peptides with 1-iodoglycals. A wide range of tri- to hexapeptides containing the Ala-Met motifs underwent Ala C-H glycosylation under the standard… read more here.
Keywords: glycosylation peptides; methionine directed; peptides methionine; stage glycosylation ... See more keywords