Mechanistic insights into the γ-elimination reaction of l-methionine catalyzed by methionine γ-lyase (MGL)
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DOI: 10.1007/s00214-017-2140-9
Abstract: The γ-elimination mechanism of l-methionine catalyzed by methionine γ-lyase was studied by employing the combined quantum mechanics and molecular (QM/MM) calculations. Based on the two crystal structures of methionine γ-lyase from Clostridium sporogenes and Citrobacter… read more here.
Keywords: methionine catalyzed; methionine lyase; catalyzed methionine; aldimine intermediate ... See more keywords
Application of l-methionine γ-lyase in chiral amino acid analysis.
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DOI: 10.1016/j.ab.2019.05.018
Abstract: Here, a conventional chiral amino acid analysis method using high-performance liquid chromatography was coupled with a sample pretreatment using l-methionine γ-lyase from Pseudomonas putida ICR 3460 for the selective analysis of l-methionine and l-tryptophan. The… read more here.
Keywords: sample; chiral amino; methionine; methionine lyase ... See more keywords
A Computational Model for the PLP-Dependent Enzyme Methionine γ-Lyase
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DOI: 10.3389/fmolb.2022.886358
Abstract: Pyridoxal-5′-phosphate (PLP) is a cofactor in the reactions of over 160 enzymes, several of which are implicated in diseases. Methionine γ-lyase (MGL) is of interest as a therapeutic protein for cancer treatment. It binds PLP… read more here.
Keywords: methionine lyase; mgl; model; plp ... See more keywords
Methionine γ-Lyase-Daidzein in Combination with S-Propyl-L-cysteine Sulfoxide as a Targeted Prodrug Enzyme System for Malignant Solid Tumor Xenografts
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DOI: 10.3390/ijms231912048
Abstract: The purpose of this study was to determine the anticancer effect of dipropyl thiosulfinate produced in situ by the pharmacological pair: (1) conjugated with daidzein C115H methionine γ-lyase (EC 4.4.1.11, C115H MGL-Dz) and (2) the… read more here.
Keywords: methionine lyase; cysteine sulfoxide; solid tumor; tumor ... See more keywords
Structural Basis of the Inhibition of L-Methionine γ-Lyase from Fusobacterium nucleatum
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DOI: 10.3390/ijms24021651
Abstract: Fusobacterium nucleatum is a lesion-associated obligate anaerobic pathogen of destructive periodontal disease; it is also implicated in the progression and severity of colorectal cancer. Four genes (FN0625, FN1055, FN1220, and FN1419) of F. nucleatum are… read more here.
Keywords: fn1419; fusobacterium nucleatum; methionine lyase; gallic acid ... See more keywords