Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming.
Sign Up to like & getrecommendations! Published in 2020 at "Cell metabolism"
DOI: 10.1016/j.cmet.2020.01.006
Abstract: Epigenetic modifications on DNA and histones regulate gene expression by modulating chromatin accessibility to transcription machinery. Here we identify methionine as a key nutrient affecting epigenetic reprogramming in CD4+ T helper (Th) cells. Using metabolomics,… read more here.
Keywords: metabolism shapes; methionine; methionine metabolism; epigenetic reprogramming ... See more keywords
Dysregulation of methionine metabolism in multiple sclerosis
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DOI: 10.1016/j.neuint.2017.10.011
Abstract: &NA; We report a significant reduction in plasma methionine concentrations in relapse remitting multiple sclerosis (MS) patients compared to controls. In vivo studies demonstrate that changes in peripheral methionine levels in mice can regulate histone… read more here.
Keywords: methionine metabolism; multiple sclerosis; dysregulation methionine;
Nutrient availability shapes methionine metabolism in p16/MTAP-deleted cells
Sign Up to like & getrecommendations! Published in 2019 at "Science Advances"
DOI: 10.1126/sciadv.aav7769
Abstract: Nutrient availability is found to determine methionine metabolism. Codeletions of gene loci containing tumor suppressors and neighboring metabolic enzymes present an attractive synthetic dependency in cancers. However, the impact that these genetic events have on… read more here.
Keywords: metabolism; p16; nutrient availability; methionine metabolism ... See more keywords
Methionine deficiency facilitates antitumour immunity by altering m6A methylation of immune checkpoint transcripts
Sign Up to like & getrecommendations! Published in 2022 at "Gut"
DOI: 10.1136/gutjnl-2022-326928
Abstract: Objective Methionine metabolism is involved in a myriad of cellular functions, including methylation reactions and redox maintenance. Nevertheless, it remains unclear whether methionine metabolism, RNA methylation and antitumour immunity are molecularly intertwined. Design The antitumour… read more here.
Keywords: m6a methylation; antitumour immunity; immunity; methionine metabolism ... See more keywords
A novel methionine metabolism-related signature predicts prognosis and immunotherapy response in lung adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2023 at "Aging"
DOI: 10.18632/aging.204687
Abstract: Recent research revealed methionine metabolism as a key mediator of tumor initiation and immune evasion. However, the relationship between methionine metabolism and tumor microenvironment (TME) in lung adenocarcinoma (LUAD) remains unknown. Here, we comprehensively analyzed… read more here.
Keywords: immunotherapy; metabolism; lung adenocarcinoma; methionine metabolism ... See more keywords
The Lysophospholipase PNPLA7 Controls Hepatic Choline and Methionine Metabolism
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DOI: 10.3390/biom13030471
Abstract: The in vivo roles of lysophospholipase, which cleaves a fatty acyl ester of lysophospholipid, remained unclear. Recently, we have unraveled a previously unrecognized physiological role of the lysophospholipase PNPLA7, a member of the Ca2+-independent phospholipase… read more here.
Keywords: methionine metabolism; pnpla7; methionine; choline methionine ... See more keywords
Blockade LAT1 Mediates Methionine Metabolism to Overcome Oxaliplatin Resistance under Hypoxia in Renal Cell Carcinoma
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DOI: 10.3390/cancers14102551
Abstract: Simple Summary The transformation and mechanism of methionine metabolism of renal cell carcinoma (RCC) under a hypoxic microenvironment is not well understood as yet. This study illustrated that the reprogramming of methionine metabolism and the… read more here.
Keywords: cell carcinoma; rcc; renal cell; methionine metabolism ... See more keywords
Sensing and Signaling of Methionine Metabolism
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DOI: 10.3390/metabo11020083
Abstract: Availability of the amino acid methionine shows remarkable effects on the physiology of individual cells and whole organisms. For example, most cancer cells, but not normal cells, are hyper dependent on high flux through metabolic… read more here.
Keywords: methionine; signaling methionine; methionine metabolism; physiology ... See more keywords