A protein functionalization platform based on selective reactions at methionine residues
Sign Up to like & getrecommendations! Published in 2018 at "Nature"
DOI: 10.1038/s41586-018-0608-y
Abstract: Nature has a remarkable ability to carry out site-selective post-translational modification of proteins, therefore enabling a marked increase in their functional diversity1. Inspired by this, chemical tools have been developed for the synthetic manipulation of… read more here.
Keywords: methionine residues; protein functionalization; platform; biology ... See more keywords
Negating coordinative cysteine and methionine residues during metathesis of unprotected peptides.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d3cc01476b
Abstract: Ru-Alkylidene catalysed olefin metathesis generates metabolically stable cystine bridge peptidomimetics with defined geometry. Deleterious coordinative bonding to the catalyst by sulfur-containing functionality found in cysteine and methionine residues can be negated by in situ and… read more here.
Keywords: methionine residues; coordinative cysteine; metathesis; cysteine methionine ... See more keywords
MetOSite: an integrated resource for the study of methionine residues sulfoxidation
Sign Up to like & getrecommendations! Published in 2019 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btz462
Abstract: MOTIVATION The oxidation of protein-bound methionine to form methionine sulfoxide has traditionally been regarded as an oxidative damage. However, growing evidences support the view of this reversible reaction also as a regulatory post-translational modification. Thus,… read more here.
Keywords: methionine residues; integrated resource; methionine; metosite integrated ... See more keywords