Effects of dietary methionine restriction on age‐related changes in perivascular and beiging adipose tissues in the mouse
Sign Up to like & getrecommendations! Published in 2022 at "Obesity"
DOI: 10.1002/oby.23583
Abstract: Perivascular adipose tissue (PVAT) regulates vascular health. Dietary methionine restriction (MetR) impacts age‐related adiposity, and this study addresses its effects in PVAT. read more here.
Keywords: dietary methionine; methionine restriction; effects dietary; age related ... See more keywords
Total Methionine Restriction Treatment of Cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8796-2_13
Abstract: This chapter reviews how total methionine (MET) restriction (MR) of a human brain tumor xenograft, effected by the combination of recombinant L-methionine-α-deamino-γ-lyase (rMETase) and a MET-free diet, greatly potentiates standard chemotherapy for brain tumors in… read more here.
Keywords: treatment; methionine restriction; total methionine; growth ... See more keywords
Methionine restriction exposes a targetable redox vulnerability of triple-negative breast cancer cells by inducing thioredoxin reductase
Sign Up to like & getrecommendations! Published in 2021 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-021-06398-y
Abstract: Tumor cells are dependent on the glutathione and thioredoxin antioxidant pathways to survive oxidative stress. Since the essential amino acid methionine is converted to glutathione, we hypothesized that methionine restriction (MR) would deplete glutathione and… read more here.
Keywords: breast cancer; methionine restriction; thioredoxin; tnbc ... See more keywords
S-adenosyl-L-homocysteine extends lifespan through methionine restriction effects.
Sign Up to like & getrecommendations! Published in 2022 at "Aging cell"
DOI: 10.1111/acel.13604
Abstract: Methionine restriction (MetR) can extend lifespan and delay the onset of aging-associated pathologies in most model organisms. Previously, we showed that supplementation with the metabolite S-adenosyl-L-homocysteine (SAH) extends lifespan and activates the energy sensor AMP-activated… read more here.
Keywords: lifespan methionine; adenosyl homocysteine; extends lifespan; homocysteine extends ... See more keywords
Intermittent methionine restriction reduces IGF‐1 levels and produces similar healthspan benefits to continuous methionine restriction
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13629
Abstract: A sustained state of methionine restriction (MR) dramatically extends the healthspan of several model organisms. For example, continuously methionine‐restricted rodents have less age‐related pathology and are up to 45% longer‐lived than controls. Promisingly, MR is… read more here.
Keywords: restriction; healthspan benefits; methionine restriction; similar healthspan ... See more keywords
Abstract 2839: Methionine restriction radiosensitizes KRAS mutant rectal cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2839
Abstract: Purpose/Objective(s): Radiation therapy (RT) is the standard of care in patients with locally advanced rectal cancer, but not all patients respond equally to RT. KRAS-mutated (KRASmut) cancer cells are highly radioresistance and require higher levels… read more here.
Keywords: methionine; radiation; rectal cancer; methionine restriction ... See more keywords
Methionine Restriction Diet Improves Metabolic Function in Obese C57BL/6 Female Mice via AMPK/SIRT1/PGC1α Pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Food and Nutrition Research"
DOI: 10.12691/jfnr-7-2-1
Abstract: Methionine restriction has been proven to reverse age and obesity related metabolic diseases. Basically, MR regulates energy homeostasis in the whole body contributing to enhanced insulin sensitivity and improved redox status. There is no studies… read more here.
Keywords: methionine; via ampk; ampk sirt1; methionine restriction ... See more keywords
Dysbiosis of Gut Microbiota and Lipidomics of Content Induced by Dietary Methionine Restriction in Rice Field Eel (Monopterus albus)
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.917051
Abstract: An 8-week feeding trial was conducted using the rice field eel (Monopterus albus) with six isonitrogenous and isoenergetic experimental diets of basic feed supplemented with different levels of methionine (0, 2, 4, 6, 8, or… read more here.
Keywords: eel; gut microbiota; methionine; rice ... See more keywords
Effect of Methionine Restriction on Aging: Its Relationship to Oxidative Stress
Sign Up to like & getrecommendations! Published in 2021 at "Biomedicines"
DOI: 10.3390/biomedicines9020130
Abstract: Enhanced oxidative stress is closely related to aging and impaired metabolic health and is influenced by diet-derived nutrients and energy. Recent studies have shown that methionine restriction (MetR) is related to longevity and metabolic health… read more here.
Keywords: methionine restriction; metabolic health; stress; oxidative stress ... See more keywords
Metabolomics Based on 1H-NMR Reveal the Regulatory Mechanisms of Dietary Methionine Restriction on Splenic Metabolic Dysfunction in Obese Mice
Sign Up to like & getrecommendations! Published in 2021 at "Foods"
DOI: 10.3390/foods10102439
Abstract: Methionine restriction (MR) has been reported to have many beneficial health effects, including stress resistance enhancement and lifespan extension. However, the effects of MR on the splenic metabolic dysfunction induced by obesity in mice remain… read more here.
Keywords: dysfunction; methionine restriction; splenic metabolic; mice ... See more keywords
Sex-Specific Effects of Dietary Methionine Restriction on the Intestinal Microbiome
Sign Up to like & getrecommendations! Published in 2020 at "Nutrients"
DOI: 10.3390/nu12030781
Abstract: Dietary methionine restriction is associated with improved health outcomes and an increase in lifespan in animal models. We have previously shown that an increase in dietary methionine induces alteration in the intestinal microbiome. The composition… read more here.
Keywords: methionine restriction; methionine; intestinal microbiome; dietary methionine ... See more keywords