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   Articles with "methionine sulfoxide" as a keyword



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Characterization of macrophage phenotype, redox, and purinergic response upon chronic treatment with methionine and methionine sulfoxide in mice

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recommendations! Published in 2020 at "Amino Acids"

DOI: 10.1007/s00726-020-02841-4

Abstract: Hypermethioninemia is a disorder characterized by high plasma levels of methionine (Met) and its metabolites such as methionine sulfoxide (MetO). Studies have reported associated inflammatory complications, but the mechanisms involved in the pathophysiology of hypermethioninemia… read more here.

Keywords: purinergic; methionine; upon chronic; met meto ... See more keywords
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Acute administration of methionine and/or methionine sulfoxide impairs redox status and induces apoptosis in rat cerebral cortex

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recommendations! Published in 2017 at "Metabolic Brain Disease"

DOI: 10.1007/s11011-017-0054-9

Abstract: High plasma levels of methionine (Met) and its metabolites such as methionine sulfoxide (MetO) may occur in several genetic abnormalities. Patients with hypermethioninemia can present neurological dysfunction; however, the neurotoxicity mechanisms induced by these amino… read more here.

Keywords: cerebral cortex; meto; meto met; met meto ... See more keywords
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Methionine sulfoxide reductase A protects against lipopolysaccharide-induced septic shock via negative regulation of the proinflammatory responses.

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recommendations! Published in 2017 at "Archives of biochemistry and biophysics"

DOI: 10.1016/j.abb.2017.08.008

Abstract: Methionine sulfoxide reductase A (MsrA) is a major antioxidant enzyme that specifically catalyzes the reduction of methionine S-sulfoxide. In this study, we used MsrA gene-knockout (MsrA-/-) mice and bone marrow-derived macrophages (BMDMs) to investigate the… read more here.

Keywords: sulfoxide reductase; msra; lps induced; msra mice ... See more keywords
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Methionine sulfoxide reductase B1 regulates proliferation and invasion by affecting mitogen-activated protein kinase pathway and epithelial-mesenchymal transition in u2os cells.

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recommendations! Published in 2018 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2018.01.151

Abstract: Methionine sulfoxide reductase B1 (MsrB1), a member of the selenoprotein family and contributes significantly to the reduction of methionine sulfoxides produced from reactive oxygen species (ROS). However, few studies have examined the role of MsrB1… read more here.

Keywords: sulfoxide reductase; proliferation invasion; invasion; u2os cells ... See more keywords
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Investigation of Methionine Sulfoxide Formation as a Regulator of Proteolysis

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recommendations! Published in 2017 at "Biophysical Journal"

DOI: 10.1016/j.bpj.2016.11.1117

Abstract: The oxidation status of the methionine in the Tyr-Met cleavage site of von Willebrand Factor affects its rate of proteolysis and therefore oxidation has been proposed as a potential regulator of coagulation. More generally, little… read more here.

Keywords: proteolysis; oxidation; cleavage; methionine ... See more keywords

A methionine-R-sulfoxide reductase, OsMSRB5, is required for rice defense against copper toxicity

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recommendations! Published in 2018 at "Environmental and Experimental Botany"

DOI: 10.1016/j.envexpbot.2018.04.006

Abstract: Abstract Methionine sulfoxide reductases (MSRs), a family of enzymes catalyzing the conversion of methionine from its oxidized form into its reduced form, has a pivotal role in responding to oxidative stress. In the present study,… read more here.

Keywords: sulfoxide reductase; rice; methionine; copper ... See more keywords
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Myristoylated Methionine Sulfoxide Reductase A Interacts with the Lipid-Binding Protein

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recommendations! Published in 2017 at "Free Radical Biology and Medicine"

DOI: 10.1016/j.freeradbiomed.2017.10.031

Abstract: Reactive oxygen species (ROS) are produced by a variety of cellular processes including metabolic activity, mitochondria, cellular signaling, and oncogene activity. Methionine sulfoxide reductase A (MsrA) is an antioxidant enzyme that can reduce methionine sulfoxide… read more here.

Keywords: protein; sulfoxide reductase; myristoylated msra; stard3 ... See more keywords
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Drosophila Methionine sulfoxide reductase A is not a methionine oxidase

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recommendations! Published in 2017 at "Free Radical Biology and Medicine"

DOI: 10.1016/j.freeradbiomed.2017.10.043

Abstract: Methionine sulfoxide reductase A (MsrA) stereospecifically catalyzes the reduction of S-methionine sulfoxide to methionine and is important in defense against oxidative stress. Recently, we reported that mammalian methionine sulfoxide reductase A stereospecifically and selectively oxidizes… read more here.

Keywords: drosophila; sulfoxide reductase; methionine; methionine oxidase ... See more keywords
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Abscisic acid-dependent nitric oxide pathway and abscisic acid-independent nitric oxide routes differently modulate NaCl stress induction of the gene expression of methionine sulfoxide reductase A and B in rice roots.

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recommendations! Published in 2018 at "Journal of plant physiology"

DOI: 10.1016/j.jplph.2018.10.019

Abstract: The methionine residues of proteins are the preferred targets of oxidation by reactive oxygen species resulting in the formation of methionine sulfoxide (MetSO), which impairs protein function. Methionine sulfoxide reductase A and B (MSR) catalyze… read more here.

Keywords: sulfoxide reductase; abscisic acid; expression; nitric oxide ... See more keywords
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An Intramolecular Charge Transfer-Förster Resonance Energy Transfer Integrated Unimolecular Platform for Two-Photon Ratiometric Fluorescence Sensing of Methionine Sulfoxide Reductases in Live-Neurons and Mouse Brain Tissues.

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recommendations! Published in 2022 at "Analytical chemistry"

DOI: 10.1021/acs.analchem.2c00415

Abstract: Oxidative stress in organisms is a factor leading to a series of diseases including tumors and neurological disorders, while methionine sulfoxide reductases (Msrs) may provide an antioxidant and self-repair mechanism through redox cycles of methionine… read more here.

Keywords: unimolecular platform; two photon; transfer; msrs ... See more keywords
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Discovery and Rational Mutagenesis of Methionine Sulfoxide Reductase Biocatalysts To Expand the Substrate Scope of the Kinetic Resolution of Chiral Sulfoxides

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recommendations! Published in 2023 at "ACS Catalysis"

DOI: 10.1021/acscatal.3c00372

Abstract: Methionine sulfoxide reductase A (MsrA) enzymes have recently found applications as nonoxidative biocatalysts in the enantioselective kinetic resolution of racemic sulfoxides. This work describes the identification of selective and robust MsrA biocatalysts able to catalyze… read more here.

Keywords: chiral sulfoxides; expand substrate; sulfoxide reductase; resolution ... See more keywords