A validated chiral chromatographic method for the enantiomeric separation of acalabrutinib.
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DOI: 10.1002/chir.23485
Abstract: Acalabrutinib is aided in the treatment of various cancers, which acts by inhibiting Bruton tyrosine kinase. Acalabrutinib belongs to the imidazopyrazine class consisting of a chiral carbon, resulting in two enantiomers. Currently, no methods exist… read more here.
Keywords: validated chiral; acalabrutinib; chromatographic method; chiral chromatographic ... See more keywords
Development, Robustness by Design Expert and Validation of a Method for Enantiomeric Impurity Content Determination in Pretomanid Drug Substance and Pharmaceutical Dosage Form.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chromatographic science"
DOI: 10.1093/chromsci/bmac090
Abstract: For the purpose of identifying enantiomeric impurities in the drug substance and pharmaceutical dosage forms of the novel anti-TB medication pretomanid, an RP-high-performance liquid chromatography method was devised. To ensure the robustness of the optimized… read more here.
Keywords: substance pharmaceutical; pharmaceutical dosage; drug substance; robustness ... See more keywords