Optimized method for the quantification of pyruvic acid in onions by microplate reader and confirmation by high resolution mass spectra.
Sign Up to like & getrecommendations! Published in 2018 at "Food chemistry"
DOI: 10.1016/j.foodchem.2017.08.099
Abstract: The present study describes the rapid microplate method to determine pyruvic acid content in different varieties of onions. Onion juice was treated with 2,4-dinitrophenylhydrazine to obtain hydrazone, which was further treated with potassium hydroxide to… read more here.
Keywords: acid onions; quantification pyruvic; method quantification; pyruvic acid ... See more keywords
A Validated, Fast Method for Quantification of Sterols and Gut Microbiome Derived 5α/β-Stanols in Human Feces by Isotope Dilution LC-High-Resolution MS.
Sign Up to like & getrecommendations! Published in 2018 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.8b01278
Abstract: There has been an increasing interest during recent years in the role of the gut microbiome on health and disease. Therefore, metabolites in human feces related to microbial activity are attractive surrogate marker to track… read more here.
Keywords: high resolution; method quantification; human feces; microbiome derived ... See more keywords
Optimization and Validation of an HPAEC-PAD Method for the Quantification of FODMAPs in Cereals and Cereal-Based Products.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.9b00382
Abstract: This study presents an analytical method for the quantification of fermentable oligo-, di-, and monosaccharides and polyols (FODMAPs) in cereals and cereal-based products, considering diverse ingredients, such as different cereals in addition to wheat, pulses,… read more here.
Keywords: cereals cereal; cereal based; method quantification; method ... See more keywords
New method for quantification of gasotransmitter hydrogen sulfide in biological matrices by LC-MS/MS
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep46278
Abstract: Hydrogen sulfide exists widely in mammalian tissues and plays a vital role in physiological and pathophysiological processes. However, striking differences with orders of magnitude were observed for the detected hydrogen sulfide concentrations in biological matrices… read more here.
Keywords: hydrogen; method quantification; new method; biological matrices ... See more keywords
LC-MS Compatible Chromatographic Method for Quantification of Potential Organic Impurities of Elagolix Sodium in Tablet Dosage Form with Identification of Major Degradation Products.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of AOAC International"
DOI: 10.1093/jaoacint/qsad019
Abstract: BACKGROUND Elagolix is a Gonadotropin-Releasing Hormone (GnRH) modulator and used for pain relief during endometriosis. OBJECTIVE The present research was performed to develop and validate a simple, novel, fast, sensitive and cost-effective LC-MS compatible chromatographic… read more here.
Keywords: organic impurities; method quantification; elagolix sodium; impurities elagolix ... See more keywords
A Streamlined Method for Quantification of Apolipoprotein A1 in Human Plasma by LC-MS/MS.
Sign Up to like & getrecommendations! Published in 2018 at "Clinical chemistry"
DOI: 10.1373/clinchem.2018.293530
Abstract: To the Editor: Apolipoprotein A1 (apoA1) is the major protein component of high-density lipoprotein particles in blood, and its concentration in serum and plasma is a marker of atherosclerotic cardiovascular diseases. Clinical laboratories commonly use… read more here.
Keywords: quantification apolipoprotein; plasma; streamlined method; method quantification ... See more keywords
A Simple LC-MS/MS Method for the Quantification of PDA-66 in Human Plasma
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27030974
Abstract: The treatment of cancer is one of the most important pharmacotherapeutic challenges. To this end, chemotherapy has for some time been complemented by targeted therapies against specific structures. PDA-66, a structural analogue of the inhibitor… read more here.
Keywords: human plasma; quantification; method quantification; pda human ... See more keywords
Accurate Mass Identification of an Interfering Water Adduct and Strategies in Development and Validation of an LC-MS/MS Method for Quantification of MPI8, a Potent SARS-CoV-2 Main Protease Inhibitor, in Rat Plasma in Pharmacokinetic Studies
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15060676
Abstract: MPI8, a peptidyl aldehyde, is a potent antiviral agent against coronavirus. Due to unique tri-peptide bonds and the formyl functional group, the bioassay of MPI8 in plasma was challenged by a strong interference from water… read more here.
Keywords: quantification; method quantification; mpi8; water ... See more keywords
Quantification of Allantoin in Yams (Dioscorea sp.) Using a 1H NMR Spectroscopic Method
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Microbiology and Biotechnology"
DOI: 10.4014/jmb.2301.01009
Abstract: Allantoin is an abundant component of yams and has been known as a skin protectant due to its pharmacological activities. In previous methods for allantoin determination using high-performance liquid chromatography (HPLC), the separation was unsatisfactory.… read more here.
Keywords: quantification; method quantification; yams dioscorea; allantoin yams ... See more keywords
Validated UHPLC-MS/MS method for quantification of doxycycline in abdominal aortic aneurysm patients.
Sign Up to like & getrecommendations! Published in 2018 at "Bioanalysis"
DOI: 10.4155/bio-2017-0263
Abstract: AIM There is a strong evidence that doxycycline can benefit abdominal aortic aneurysms patients because of its ability to inhibit matrix metalloproteinase enzymes. There is a need for a specific quantification method for doxycycline in… read more here.
Keywords: validated uhplc; method quantification; method; uhplc method ... See more keywords
Stability-indicating LC Method for Quantification of Azelnidipine: Synthesis and Characterization of Oxidative Degradation Product
Sign Up to like & getrecommendations! Published in 2021 at "Turkish journal of pharmaceutical sciences"
DOI: 10.4274/tjps.galenos.2020.76753
Abstract: Objectives In the work presented here, the degradation behavior of azelnidipine under diverse forced degradation conditions was studied. A stability-indicating liquid chromatographic method was established which could separate and resolve azelnidipine from its degradation products.… read more here.
Keywords: degradation; degradation product; method quantification; stability indicating ... See more keywords