Quantitative Chiral Separations on KRAS Inhibitor Sotorasib by UHPLC-MS/MS: Method Validation and Enantioselective Pharmacokinetics Assessment in Rat Plasma.
Sign Up to like & getrecommendations! Published in 2025 at "Chirality"
DOI: 10.1002/chir.70037
Abstract: In this research, estimation of enantioselective pharmacokinetics and biological interconversion of sotorasib were investigated. This is the first report for the novel chiral liquid chromatography-tandem mass spectrometry method for the enantioselective pharmacokinetics determination in biological… read more here.
Keywords: method; method validation; sotorasib; quantitative chiral ... See more keywords
Method Validation Using Normal and Weighted Linear Regression Models for Quantification of Pesticides in Mango (Mangifera indica L.) Samples
Sign Up to like & getrecommendations! Published in 2018 at "Chromatographia"
DOI: 10.1007/s10337-018-3483-7
Abstract: A fast and efficient method was developed and validated for the determination of pesticides in mangos, which uses the QuEChERS citrate and gas chromatography–mass spectrometry (GC–MS) techniques. A detailed statistical analysis was performed to study… read more here.
Keywords: using normal; normal weighted; weighted linear; method validation ... See more keywords
Enzymatic method and its validation for the micromolar assay of glucose in human serum samples.
Sign Up to like & getrecommendations! Published in 2019 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2019.113536
Abstract: This work depicts the novel chromogenic system for the assay of glucose in blood samples connected with the chelate formation of sulfosalicylic acid (SSA) with iron (Fe(III)) using glucose oxidase (GOD) presented. The purple-colored Fe-SSA… read more here.
Keywords: enzymatic method; method; serum; assay glucose ... See more keywords
LC–MS/MS method validation for the quantitation of 1-kestose in wheat flour
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Food Composition and Analysis"
DOI: 10.1016/j.jfca.2021.103930
Abstract: Abstract Fructan analysis is challenging due to several mono-, di-, and oligosaccharides as well as starch and proteins present in wheat grains which interfere with the analysis. So far, a sensitive and fully validated LC–MS/MS… read more here.
Keywords: quantitation kestose; wheat; method; method validation ... See more keywords
LC–MS/MS quantification of 20(S)-protopanaxadiol in complex biological matrices for bioanalytical method validation and pharmacokinetic analysis
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-01432-1
Abstract: 20(S)-Protopanaxadiol (PPD) is a saponin derivative of ginsenoside, with more potent biological and pharmacological activities than Rg3 and Rh2. The lack of ionizable centers leads to low mass spectrometry reactions and internal cleavage of three… read more here.
Keywords: ppd; method; method validation; mass spectrometry ... See more keywords
Method validation and residue analysis of fluoxapiprolin and its metabolites on tomato by QuEChERS method combination with liquid chromatography tandem mass spectrometry (LC-MS/MS)
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Environmental Analytical Chemistry"
DOI: 10.1080/03067319.2024.2344710
Abstract: ABSTRACT Field experiments were conducted to investigate the dissipation and persistence of fluoxapiprolin and its metabolites (BDM-pyrazole, Pyrazole-acetic acid, Pyrazole-methyl sulphinyl acid, Pyrazole-alanine and Pyrazole-alanine oxopropanoic acid). For method validation, all the samples were spiked… read more here.
Keywords: method validation; fluoxapiprolin metabolites; third application; fluoxapiprolin ... See more keywords
Design of Analytical Method Validation Protocol Evaluating Environmental Monitoring of AND Contamination on Surfaces Based on Cleaning Validation Procedures: A Multi Component RP-UHPLC Method.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chromatographic science"
DOI: 10.1093/chromsci/bmac071
Abstract: Environmental monitoring of anti-neoplastic drug (AND) residues in workplaces is crucial to limit exposure to workers who handle with them. Although wipe sampling is the most appropriate methodology to evaluate the risk, conflicting results are… read more here.
Keywords: method validation; validation; method; analytical method ... See more keywords
Cebranopadol, a novel first-in-class drug candidate: Method validation and first exploratory pharmacokinetic study in rabbits.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of veterinary pharmacology and therapeutics"
DOI: 10.1111/jvp.12948
Abstract: Cebranopadol is a novel, centrally acting, potent, first-in-class analgesic drug candidate with a unique mode of action that combines nociceptin/orphanin FQ peptide receptor and opioid peptide receptor agonism. The present study aimed to develop and… read more here.
Keywords: drug candidate; method; cebranopadol novel; method validation ... See more keywords
Method Validation and Characterization of Red Pigment in Beta vulgaris Peels and Pomaces by HPLC-UV and UHPLC-MS/MS
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Analytical Methods in Chemistry"
DOI: 10.1155/2022/2229500
Abstract: Color pigments from plant, animal, or mineral sources can be identified, separated, and quantified for various purposes. It is expected that pigments from Beta vulgaris L. peels and pomaces could be used to develop natural… read more here.
Keywords: method validation; beta vulgaris; hplc; vulgaris peels ... See more keywords
Method validation and measurement uncertainty estimation of pesticide residues in Okra by GC/HPLC
Sign Up to like & getrecommendations! Published in 2025 at "PLOS One"
DOI: 10.1371/journal.pone.0330736
Abstract: Reliability and accuracy of an analytical method is ensured by method validation technique. The present study was aimed to optimize and validate a rapid, reliable and accurate method for quantitatively determining pesticide residues of a… read more here.
Keywords: pesticide residues; method; hplc; method validation ... See more keywords
Use of logit transformation within statistical analyses of experimental results obtained as proportions: example of method validation experiments and EQA in flow cytometry
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2024.1335174
Abstract: In laboratory medicine, measurement results are often expressed as proportions of concentrations or counts. These proportions have distinct mathematical properties that can lead to unexpected results when conventional parametric statistical methods are naively applied without… read more here.
Keywords: method validation; validation experiments; logit transformation; statistical analyses ... See more keywords