Methotrexate mediates the integrity of intestinal stem cells partly through nitric oxide-dependent Wnt/β-catenin signaling in methotrexate-induced rat ileal mucositis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2022.01.002
Abstract: This study aimed to elucidate the role of nitric oxide (NO) in intestinal stem cells in methotrexate-induced ileal mucositis in rats. Methotrexate induced the mRNA expressions of the Wnt/β-catenin target genes Wnt3a, Sox9, and Lgr5… read more here.
Keywords: intestinal stem; methotrexate; wnt catenin; stem cells ... See more keywords
Glabridin ameliorates methotrexate-induced liver injury via attenuation of oxidative stress, inflammation, and apoptosis.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119583
Abstract: Despite unprecedented advances in modern medicine, no safe and effective drug is available to date for oral administration to combat drug-induced liver injury, which is a vital concern nowadays. The present study deals with the… read more here.
Keywords: methotrexate induced; liver injury; induced liver; glabridin ... See more keywords
Thymoquinone Augments Methotrexate-Induced Apoptosis on Osteosarcoma Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Drug research"
DOI: 10.1055/a-1775-7908
Abstract: BACKGROUND Osteosarcoma (OS) as the most frequent primary bone malignancy in children and adolescents has a short survival rate in advanced stages. Alternative herbal medicines with fewer side effects or the potency to protect common… read more here.
Keywords: apoptosis; augments methotrexate; methotrexate induced; apoptotic factors ... See more keywords
Association between SLCO1B1 polymorphism and methotrexate-induced hepatotoxicity: a systematic review and meta-analysis.
Sign Up to like & getrecommendations! Published in 2021 at "Anti-cancer drugs"
DOI: 10.1097/cad.0000000000001125
Abstract: Reports on the association between the solute carrier organic anion transporter 1B1 (SLCO1B1) T521C polymorphism and methotrexate-induced hepatotoxicity in patients with malignancies are inconsistent. This meta-analysis evaluated the association between the SLCO1B1 T521C polymorphism and… read more here.
Keywords: meta analysis; methotrexate induced; polymorphism; hepatotoxicity ... See more keywords
Response to: ‘HLA-A* 31:01 is not associated with the development of methotrexate pneumonitis in the UK population: results from a genome wide association study’ by Bluett et al
Sign Up to like & getrecommendations! Published in 2017 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2017-211518
Abstract: We appreciate the comments by Bluett et al 1 on our report of an association of HLA-A*31:01 with methotrexate-induced interstitial lung disease (ILD) in patients with rheumatoid arthritis (RA).2 They have tried to reveal the… read more here.
Keywords: induced ild; genome wide; methotrexate induced; hla ... See more keywords
The Encapsulation of Lycopene in Nanoliposomes Enhances Its Protective Potential in Methotrexate-Induced Kidney Injury Model
Sign Up to like & getrecommendations! Published in 2018 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2018/2627917
Abstract: Methotrexate is an antimetabolic drug with a myriad of serious side effects including nephrotoxicity, which presumably occurs due to oxidative tissue damage. Here, we evaluated the potential protective effect of lycopene, a potent antioxidant carotenoid,… read more here.
Keywords: methotrexate induced; induced kidney; urea creatinine; damage ... See more keywords
Ginkgo biloba Extract Protects against Methotrexate-Induced Hepatotoxicity: A Computational and Pharmacological Approach
Sign Up to like & getrecommendations! Published in 2020 at "Molecules"
DOI: 10.3390/molecules25112540
Abstract: Ginkgo biloba extract possess several promising biological activities; currently, it is clinically employed in the management of several diseases. This research work aimed to extrapolate the antioxidant and anti-inflammatory effects of Ginkgo biloba (Gb) in… read more here.
Keywords: ginkgo biloba; methotrexate induced; extract protects; biloba extract ... See more keywords
Fasudil Ameliorates Methotrexate-Induced Hepatotoxicity by Modulation of Redox-Sensitive Signals
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15111436
Abstract: Methotrexate (MTX) is one of the most widely used cytotoxic chemotherapeutic agents, and it is used in the treatment of different autoimmune disorders. However, the clinical applications of MTX are limited by its hepatic toxicity.… read more here.
Keywords: mtx hepatotoxicity; hepatotoxicity; methotrexate induced; induced hepatotoxicity ... See more keywords
Hypercalcemia with methotrexate pneumonitis: A rare, important and intriguing adverse event
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Postgraduate Medicine"
DOI: 10.4103/jpgm.jpgm_1180_21
Abstract: Methotrexate leading to hypercalcaemia is a rarely reported adverse event. We present three elderly patients with inflammatory arthritis who developed hypercalcemia probably due to methotrexate-induced granulomatous pneumonitis. All patients presented with worsening non-productive cough with… read more here.
Keywords: hypercalcemia; methotrexate; adverse event; methotrexate induced ... See more keywords