Metabolome Analysis Reveals Excessive Glycolysis via PI3K/AKT/mTOR and RAS/MAPK Signaling in Methotrexate-Resistant Primary CNS Lymphoma–Derived Cells
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DOI: 10.1158/1078-0432.ccr-18-3851
Abstract: Purpose: Metabolome analysis is an emerging method that provides insight into intracellular and physiologic responses. Methotrexate (MTX) is an antifolate that suppresses DNA syntheses by inhibiting dihydrofolate reductase. High-dose methotrexate treatment with deferred radiotherapy is… read more here.
Keywords: derived cells; methotrexate; methotrexate resistant; metabolism ... See more keywords