Design and Synthesis of C-1 Methoxycarbonyl Derivative of Narciclasine and Its Biological Activity
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DOI: 10.3390/molecules27123809
Abstract: A 15-step chemoenzymatic total synthesis of C-1 methoxycarbonyl narciclasine (10) was accomplished. The synthesis began with the toluene dioxygenase-mediated dihydroxylation of ortho-dibromobenzene to provide the corresponding cis-dihydrodiol (12) as a single enantiomer. Further key steps… read more here.
Keywords: design synthesis; methoxycarbonyl derivative; synthesis; synthesis methoxycarbonyl ... See more keywords