Synthesis and biological evaluation of new 2-methoxyestradiol derivatives: Potent inhibitors of angiogenesis and tubulin polymerization.
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DOI: 10.1016/j.bioorg.2021.104988
Abstract: Here, we report the structural optimization of a hit natural compound, 2-ME2 (2-methoxyestradiol), which exhibited inhibitory activity but low potency on tubulin polymerization, anti- angiogenesis, MCF-7 proliferation and metastasis in vitro and in vivo. A… read more here.
Keywords: methoxyestradiol; polymerization; proliferation metastasis; tubulin polymerization ... See more keywords
Evidence for 2-Methoxyestradiol-Mediated Inhibition of Receptor Tyrosine Kinase RON in the Management of Prostate Cancer
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DOI: 10.3390/ijms22041852
Abstract: 2-Methoxyestradiol (2-ME2) possesses anti-tumorigenic activities in multiple tumor models with acceptable tolerability profile in humans. Incomplete understanding of the mechanism has hindered its development as an anti-tumorigenic compound. We have identified for the first-time macrophage… read more here.
Keywords: prostate; methoxyestradiol; protein; prostate cancer ... See more keywords